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Special Issue: Microbial Impact on Cholesterol and Bile Acid Metabolism
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Special Issue: Microbial Impact on Cholesterol and Bile Acid Metabolism
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Journal Article
Special Issue: Microbial Impact on Cholesterol and Bile Acid Metabolism
2022
Overview
A primary research article by Déjean et al. entitled, “Identifying a Novel Bile Salt Hydrolase from the Keystone Gut Bacterium Christensenella minuta” describes BSH activity and phylogenetic position of the C. minuta enzyme [6]. In their article, “Bile Acid Sequestrant, Sevelamer Ameliorates Hepatic Fibrosis with Reduced Overload of Endogenous Lipopolysaccharide in Experimental Nonalcoholic Steatohepatitis”, Tsuji et al. provide evidence that the bile acid sequestrant, sevelamer, reduced bile acid absorption and increased LPS excretion, inhibiting the development of murine hepatic steatohepatitis [15]. Bodo Philipp’s research group organizes the complexity of bile salt mineralization by environmental microbes into a highly accessible review entitled, “Degradation of Bile Acids by Soil and Water Bacteria” [18].
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