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Water-Soluble Polyoxometal Clusters of Molybdenum (V) with Pyrazole and Triazole: Synthesis and Study of Cytotoxicity and Antiviral Activity
by
Alekseev, Alexander Y.
, Yanshole, Vadim V.
, Konkova, Anna V.
, Shestopalov, Aleksander M.
, Eltsov, Ilia V.
, Pozmogova, Tatiana N.
, Solomatina, Maria V.
, Shestopalov, Michael A.
, Kuratieva, Natalia V.
, Ivanov, Anton A.
, Savina, Iulia V.
, Nokhova, Alina R.
, Evtushok, Darya V.
in
Antifungal agents
/ antiviral activity
/ Antiviral agents
/ Antiviral drugs
/ Aqueous solutions
/ Avian influenza
/ Avian influenza viruses
/ Crystal structure
/ Cytotoxicity
/ Hydrogen bonds
/ Ligands
/ Mass spectrometry
/ Molybdenum
/ polyoxometal cluster
/ pyrazole
/ Scientific imaging
/ triazole
/ Triazoles
2023
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Water-Soluble Polyoxometal Clusters of Molybdenum (V) with Pyrazole and Triazole: Synthesis and Study of Cytotoxicity and Antiviral Activity
by
Alekseev, Alexander Y.
, Yanshole, Vadim V.
, Konkova, Anna V.
, Shestopalov, Aleksander M.
, Eltsov, Ilia V.
, Pozmogova, Tatiana N.
, Solomatina, Maria V.
, Shestopalov, Michael A.
, Kuratieva, Natalia V.
, Ivanov, Anton A.
, Savina, Iulia V.
, Nokhova, Alina R.
, Evtushok, Darya V.
in
Antifungal agents
/ antiviral activity
/ Antiviral agents
/ Antiviral drugs
/ Aqueous solutions
/ Avian influenza
/ Avian influenza viruses
/ Crystal structure
/ Cytotoxicity
/ Hydrogen bonds
/ Ligands
/ Mass spectrometry
/ Molybdenum
/ polyoxometal cluster
/ pyrazole
/ Scientific imaging
/ triazole
/ Triazoles
2023
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Water-Soluble Polyoxometal Clusters of Molybdenum (V) with Pyrazole and Triazole: Synthesis and Study of Cytotoxicity and Antiviral Activity
by
Alekseev, Alexander Y.
, Yanshole, Vadim V.
, Konkova, Anna V.
, Shestopalov, Aleksander M.
, Eltsov, Ilia V.
, Pozmogova, Tatiana N.
, Solomatina, Maria V.
, Shestopalov, Michael A.
, Kuratieva, Natalia V.
, Ivanov, Anton A.
, Savina, Iulia V.
, Nokhova, Alina R.
, Evtushok, Darya V.
in
Antifungal agents
/ antiviral activity
/ Antiviral agents
/ Antiviral drugs
/ Aqueous solutions
/ Avian influenza
/ Avian influenza viruses
/ Crystal structure
/ Cytotoxicity
/ Hydrogen bonds
/ Ligands
/ Mass spectrometry
/ Molybdenum
/ polyoxometal cluster
/ pyrazole
/ Scientific imaging
/ triazole
/ Triazoles
2023
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Water-Soluble Polyoxometal Clusters of Molybdenum (V) with Pyrazole and Triazole: Synthesis and Study of Cytotoxicity and Antiviral Activity
Journal Article
Water-Soluble Polyoxometal Clusters of Molybdenum (V) with Pyrazole and Triazole: Synthesis and Study of Cytotoxicity and Antiviral Activity
2023
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Overview
Among well-studied and actively developing compounds are polyoxometalates (POMs), which show application in many fields. Extending this class of compounds, we introduce a new subclass of polyoxometal clusters (POMCs) [Mo12O28(μ-L)8]4− (L = pyrazolate (pz) or triazolate (1,2,3-trz or 1,2,4-trz)), structurally similar to POM, but containing binuclear Mo2O4 clusters linked by bridging oxo- and organic ligands. The complexes obtained by ampoule synthesis from the binuclear cluster [Mo2O4(C2O4)2(H2O)2]2− in a melt of an organic ligand are soluble and stable in aqueous solutions. In addition to the detailed characterization in solid state and in aqueous solution, the biological properties of the compounds on normal and cancer cells were investigated, and antiviral activity against influenza A virus (subtype H5N1) was demonstrated.
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