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On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system
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On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system
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Journal Article
On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system
2016
Overview
Pharmaceutical manufacturing typically uses batch processing at multiple locations. Disadvantages of this approach include long production times and the potential for supply chain disruptions. As a preliminary demonstration of an alternative approach, we report here the continuous-flow synthesis and formulation of active pharmaceutical ingredients in a compact, reconfigurable manufacturing platform. Continuous end-to-end synthesis in the refrigerator-sized [1.0 meter (width) × 0.7 meter (length) × 1.8 meter (height)] system produces sufficient quantities per day to supply hundreds to thousands of oral or topical liquid doses of diphenhydramine hydrochloride, lidocaine hydrochloride, diazepam, and fluoxetine hydrochloride that meet U.S. Pharmacopeia standards. Underlying this flexible plug-and-play approach are substantial enabling advances in continuous-flow synthesis, complex multistep sequence telescoping, reaction engineering equipment, and real-time formulation.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Chemistry, Pharmaceutical - methods
/ Chimie
/ Continuous-flow manufacturing
/ Diazepam - chemical synthesis
/ Diphenhydramine - chemical synthesis
/ Lidocaine - chemical synthesis
/ Pharmaceutical Preparations - chemical synthesis
/ Pharmaceutical Preparations - standards
