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Beta-Cell Mass in Obesity and Type 2 Diabetes, and Its Relation to Pancreas Fat: A Mini-Review
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Beta-Cell Mass in Obesity and Type 2 Diabetes, and Its Relation to Pancreas Fat: A Mini-Review
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Journal Article
Beta-Cell Mass in Obesity and Type 2 Diabetes, and Its Relation to Pancreas Fat: A Mini-Review
2020
Overview
Type 2 diabetes (T2DM) is characterized by insulin resistance and beta-cell dysfunction. Although insulin resistance is assumed to be a main pathophysiological feature of the development of T2DM, recent studies have revealed that a deficit of functional beta-cell mass is an essential factor for the pathophysiology of T2DM. Pancreatic fat contents increase with obesity and are suggested to cause beta-cell dysfunction. Since the beta-cell dysfunction induced by obesity or progressive decline with disease duration results in a worsening glycemic control, and treatment failure, preserving beta-cell mass is an important treatment strategy for T2DM. In this mini-review, we summarize the current knowledge on beta-cell mass, beta-cell function, and pancreas fat in obesity and T2DM, and we discuss treatment strategies for T2DM in relation to beta-cell preservation.
Publisher
MDPI AG,MDPI
Subject
/ decline
/ Diabetes
/ Diabetes Mellitus, Type 2 - etiology
/ Diabetes Mellitus, Type 2 - pathology
/ duration
/ Glucose
/ Glucose Intolerance - complications
/ Glucose Intolerance - pathology
/ Humans
/ Insulin Resistance - physiology
/ Insulin-Secreting Cells - pathology
/ mass
/ noninsulin-dependent diabetes mellitus
/ Obesity
/ Pancreas
/ Review
