Asset Details
Do you wish to reserve the book?
The Short-Chain Fatty Acid Acetate in Body Weight Control and Insulin Sensitivity
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The Short-Chain Fatty Acid Acetate in Body Weight Control and Insulin Sensitivity
Do you wish to request the book?
The Short-Chain Fatty Acid Acetate in Body Weight Control and Insulin Sensitivity
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The Short-Chain Fatty Acid Acetate in Body Weight Control and Insulin Sensitivity
2019
Overview
The interplay of gut microbiota, host metabolism, and metabolic health has gained increased attention. Gut microbiota may play a regulatory role in gastrointestinal health, substrate metabolism, and peripheral tissues including adipose tissue, skeletal muscle, liver, and pancreas via its metabolites short-chain fatty acids (SCFA). Animal and human data demonstrated that, in particular, acetate beneficially affects host energy and substrate metabolism via secretion of the gut hormones like glucagon-like peptide-1 and peptide YY, which, thereby, affects appetite, via a reduction in whole-body lipolysis, systemic pro-inflammatory cytokine levels, and via an increase in energy expenditure and fat oxidation. Thus, potential therapies to increase gut microbial fermentation and acetate production have been under vigorous scientific scrutiny. In this review, the relevance of the colonically and systemically most abundant SCFA acetate and its effects on the previously mentioned tissues will be discussed in relation to body weight control and glucose homeostasis. We discuss in detail the differential effects of oral acetate administration (vinegar intake), colonic acetate infusions, acetogenic fiber, and acetogenic probiotic administrations as approaches to combat obesity and comorbidities. Notably, human data are scarce, which highlights the necessity for further human research to investigate acetate’s role in host physiology, metabolic, and cardiovascular health.
Publisher
MDPI AG,MDPI
Subject
/ Acetic Acid - therapeutic use
/ Animals
/ appetite
/ Dietary Fiber - pharmacology
/ Dietary Fiber - therapeutic use
/ Energy Metabolism - drug effects
/ Fatty Acids, Volatile - therapeutic use
/ Gastrointestinal Hormones - metabolism
/ glucose
/ Humans
/ Insulin
/ Lipid Metabolism - drug effects
/ liver
/ obesity
/ pancreas
/ Probiotics - therapeutic use
/ Review
/ vinegars
