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The Threat of Artemisinin-Resistant Malaria
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Journal Article
The Threat of Artemisinin-Resistant Malaria
2011
Overview
Since the 1970s, when Chinese researchers demonstrated the artemisinins' antimalarial potency, artemisinin-based combination therapy has become key to malaria control. But reduced susceptibility of
Plasmodium falciparum
to artemisinin is now being seen in some places.
In the 1970s, Chinese government scientists working on a secret “Project 523” developed a new class of potent antimalarial drugs, the artemisinins or qinghaosu derivatives. In mostly unpublished work that has just been recognized by a 2011 Lasker Award to Tu Youyou, researchers in China isolated the active compounds from the plant
Artemisia annua,
tested them in mice, analyzed the chemical structure of the artemisinins, and demonstrated their high potency and rapid efficacy in human trials. Although they were widely used in China during the 1980s, only in the 1990s did the artemisinins come to wider global attention in the . . .
Publisher
Massachusetts Medical Society
