Journal Article

Evaluation of bleeding risk in patients who received pirtobrutinib in the presence or absence of antithrombotic therapy

Chatterjee, Anindya, Compte, Livia, Flinn, Ian W., Woyach, Jennifer A., Jurczak, Wojciech, Zinzani, Pier Luigi, Fakhri, Bita, Sizelove, Richard, Tam, Constantine S., Alencar, Alvaro J., Konig, Heiko, Ruppert, Amy S., Palomba, M. Lia, Tsai, Donald E., Kontos, Arrin, Cohen, Jonathon B., Lamanna, Nicole

2024

Overview

Clinical bleeding events are reported here from 773 patients with B‐cell malignancies receiving pirtobrutinib monotherapy from the phase 1/2 BRUIN study (ClinicalTrials.gov identifier: NCT03740529), either in the presence or absence of antithrombotic therapy (antithrombotic exposed [AT‐E], n = 216; antithrombotic nonexposed [AT‐NE], n = 557). Among the AT‐E cohort, 51.9% received platelet aggregation inhibitors, 36.6% received direct factor Xa inhibitors, 18.5% received heparins, 5.6% received salicylic acid for indications other than platelet aggregation inhibition, and 2.3% received thrombolytics. Warfarin was not permitted. Any‐grade bleeding/bruising events occurred in 97 patients (44.9%; 95% confidence interval [CI], 38.3–51.5) in the AT‐E cohort and 181 patients (32.5%; 95% CI, 28.6–36.4) in the AT‐NE cohort. Most bleeding/bruising events in both cohorts began within the first 6 months of treatment (AT‐E: 65.4%; AT‐NE: 72.5%). Contusion was the most common bleeding/bruising event in both cohorts (AT‐E: 22.7%; AT‐NE: 18.1%). Grade ≥3 bleeding/bruising events were reported in six patients (2.8%) in the AT‐E cohort and 11 patients (2.0%) in the AT‐NE cohort. Bleeding/bruising events requiring or prolonging hospitalization were reported in 2.3% and 1.6% of patients in the AT‐E and AT‐NE cohorts, respectively. No bleeding/bruising events led to pirtobrutinib dose reduction or permanent discontinuation in the AT‐E cohort, and one patient (0.2%) in the AT‐NE cohort experienced an event requiring dose reduction. These data support the safety of pirtobrutinib in patients requiring antithrombotic therapies.

• Publisher: John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
• Subject: Anticoagulants / antithrombotic therapy / Bleeding / Bruton tyrosine kinase inhibitor / B‐cell cancers / Cardiovascular disease / Contusions / Drug dosages / Drug withdrawal / FDA approval / Hematoma / Hemorrhage / Kinases / Lymphoma / Malignancy / Nervous system / Patients / Pharmacists / pirtobrutinib / Platelet aggregation / Salicylic acid / Sickle Cell, Thrombosis, and Classical Haematology / Stroke / Thrombocytopenia