Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury—outcomes at 6 months

by Soler, Caridad , Sandercock, Peter , Balica, Laura , Husain, Mazhar , Ulloa, Mario Izurieta , Gogichaisvili, Tamar , Jerbi, Zouheir , Nasi, Luis , Lomas, Gabrielle , Plunkett, Patrick , Yates, David , Mazairac, Guy , Shakur, Haleema , Svoboda, Petr , Arango, Miguel , El-Sayed, Hesham , Komolafe, Edward , Stocker, Reto , Trenkler, Stefan , Cottingham, Rowland , Khamis, Hussein , Wasserberg, Jonathan , Fernandes, Janice , Ludwig, Silke , Yutthakasemsunt, Surakrant , Farrell, Barbara , Roberts, Ian , Laloë, Véronique , Muñoz Sanchéz, Maria de los Angeles , Olldashi, Fatos , Edwards, Phil , Hartzenberg, Bennie , Venkataramana, N K , Golden, Nyoman

in Adults / Biological and medical sciences / Clinical outcomes / Clinical trials / Corticoids / Craniocerebral Trauma - drug therapy / Craniocerebral Trauma - mortality / Drug therapy / Follow-Up Studies / General aspects / Glucocorticoids - administration & dosage / Head injuries / Humans / Infusions, Intravenous / Injuries of the nervous system and the skull. Diseases due to physical agents / Medical sciences / Methylprednisolone - administration & dosage / Mortality / Risk Factors / Traumas. Diseases due to physical agents / Treatment Outcome

2005

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury—outcomes at 6 months

2005

Confirm

Do you wish to request the book?

Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury—outcomes at 6 months

2005

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury—outcomes at 6 months

Soler, Caridad,

Sandercock, Peter,

Balica, Laura,

Husain, Mazhar,

Ulloa, Mario Izurieta,

Gogichaisvili, Tamar,

Jerbi, Zouheir,

Nasi, Luis,

Lomas, Gabrielle,

Plunkett, Patrick,

Yates, David,

Mazairac, Guy,

Shakur, Haleema,

Svoboda, Petr,

Arango, Miguel,

El-Sayed, Hesham,

Komolafe, Edward,

Stocker, Reto,

Trenkler, Stefan,

Cottingham, Rowland,

Khamis, Hussein,

Wasserberg, Jonathan,

Fernandes, Janice,

Ludwig, Silke,

Yutthakasemsunt, Surakrant,

Farrell, Barbara,

Roberts, Ian,

Laloë, Véronique,

Muñoz Sanchéz, Maria de los Angeles,

Olldashi, Fatos,

Edwards, Phil,

Hartzenberg, Bennie,

Venkataramana, N K,

Golden, Nyoman

2005

Overview

MRC CRASH is a randomised controlled trial (ISRCTN74459797) of the effect of corticosteroids on death and disability after head injury. We randomly allocated 10 008 adults with head injury and a Glasgow Coma Scale score of 14 or less, within 8 h of injury, to a 48-h infusion of corticosteroid (methylprednisolone) or placebo. Data at 6 months were obtained for 9673 (96·7%) patients. The risk of death was higher in the corticosteroid group than in the placebo group (1248 [25·7%] vs 1075 [22·3%] deaths; relative risk 1·15, 95% CI 1·07–1·24; p=0·0001), as was the risk of death or severe disability (1828 [38·1%] vs 1728 [36·3%] dead or severely disabled; 1·05, 0·99–1·10; p=0·079). There was no evidence that the effect of corticosteroids differed by injury severity or time since injury. These results lend support to our earlier conclusion that corticosteroids should not be used routinely in the treatment of head injury.

Share this book

Add to My Shelf

Publisher

Elsevier Ltd,Lancet,Elsevier Limited

Subject

Adults

/ Biological and medical sciences

/ Clinical outcomes

/ Clinical trials

/ Corticoids

/ Craniocerebral Trauma - drug therapy

/ Craniocerebral Trauma - mortality