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Low-Dose Compared with Standard-Dose m-BACOD Chemotherapy for Non-Hodgkin's Lymphoma Associated with Human Immunodeficiency Virus Infection
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Low-Dose Compared with Standard-Dose m-BACOD Chemotherapy for Non-Hodgkin's Lymphoma Associated with Human Immunodeficiency Virus Infection
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Journal Article
Low-Dose Compared with Standard-Dose m-BACOD Chemotherapy for Non-Hodgkin's Lymphoma Associated with Human Immunodeficiency Virus Infection
1997
Overview
The human immunodeficiency virus (HIV) increases the risk of aggressive B-cell lymphoma,
1
,
2
which often presents at an advanced stage and frequently involves extranodal sites, such as the central nervous system and bone marrow.
3
–
7
In HIV-infected patients, the rate of complete response to the treatment of lymphoma with combination chemotherapy is approximately 50 percent, and the median survival is only five to six months.
4
–
6
,
8
Factors that favor longer survival include a higher number of CD4+ lymphocytes,
4
,
9
the absence of a prior diagnosis indicating progression to the acquired immunodeficiency syndrome (AIDS),
4
,
9
a Karnofsky performance score of . . .
Publisher
Massachusetts Medical Society
