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NK cell education via nonclassical MHC and non-MHC ligands
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Journal Article
NK cell education via nonclassical MHC and non-MHC ligands
2017
Overview
Natural killer （NK） cell education, a process for achieving functional maturation and self-tolerance, has been previously defined by the interaction between self-major histocompatibility complex class I （MHC-I） molecules and their specific inhibitory receptors. Over the past several years, growing evidence has highlighted the important roles of nonclassical MHC-I and non-MHC-I molecules in NK cell education. Herein, we review the current knowledge of NK cell education, with a particular focus on nonclassical MHC-I- and non-MHC-I-dependent education, and compare them with the classical MHC-I-dependent education theory. In addition, we update and extend this theory by presenting the ＇Confining Model＇, discussing cis and trans characteristics, reassessing quantity and quality control, and elucidating the redundancy of NK cell education in tumor and virus infection.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Biomedical and Life Sciences
/ Histocompatibility Antigens - immunology
/ Humans
/ Killer Cells, Natural - immunology
/ Ligands
/ MHC
/ NK细胞
/ Review
/ Signal Transduction - immunology
/ Vaccine
/ 控制方案
/ 教育理论
/ 病毒感染
/ 相互作用
/ 配体
/ 非经典
