Asset Details
MbrlCatalogueTitleDetail
Do you wish to reserve the book?
Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer
by
Speranza, Luisa
, Volpicelli, Floriana
, Colucci-D'Amato, Luca
in
Alzheimer's disease
/ Animals
/ Antidepressants
/ Antidepressive Agents - pharmacology
/ Autocrine signalling
/ BDNF
/ Binding sites
/ Brain cancer
/ Brain Neoplasms - genetics
/ Brain Neoplasms - pathology
/ Brain-derived neurotrophic factor
/ Brain-Derived Neurotrophic Factor - blood
/ Brain-Derived Neurotrophic Factor - genetics
/ Brain-Derived Neurotrophic Factor - physiology
/ Central nervous system
/ Dendritic spines
/ Dendritic structure
/ depression
/ Depression - drug therapy
/ Depression - metabolism
/ Depression - pathology
/ Developmental plasticity
/ Dopamine receptors
/ Exercise
/ Functional plasticity
/ Genes, Tumor Suppressor
/ Glioblastoma
/ Glutamatergic transmission
/ Humans
/ Kinases
/ Mental depression
/ Mental disorders
/ MicroRNAs
/ miRNAs
/ Nervous system
/ Neural plasticity
/ Neurodegeneration
/ Neurodegenerative Diseases - metabolism
/ Neurodegenerative Diseases - pathology
/ Neurogenesis
/ Neuromodulation
/ Neuronal Plasticity - drug effects
/ Neuronal Plasticity - physiology
/ Neuroprotective Agents - pharmacology
/ Neurotransmission
/ Neurotrophic factors
/ Oncogenes
/ Paracrine signalling
/ Pathogenesis
/ Physiological effects
/ Proteins
/ Review
/ Structure-function relationships
/ Synapses
/ synaptic plasticity
/ TrkB receptors
/ γ-Aminobutyric acid
2020
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
You are currently in the queue to collect this book. You will be notified once it is your turn to collect the book.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer
by
Speranza, Luisa
, Volpicelli, Floriana
, Colucci-D'Amato, Luca
in
Alzheimer's disease
/ Animals
/ Antidepressants
/ Antidepressive Agents - pharmacology
/ Autocrine signalling
/ BDNF
/ Binding sites
/ Brain cancer
/ Brain Neoplasms - genetics
/ Brain Neoplasms - pathology
/ Brain-derived neurotrophic factor
/ Brain-Derived Neurotrophic Factor - blood
/ Brain-Derived Neurotrophic Factor - genetics
/ Brain-Derived Neurotrophic Factor - physiology
/ Central nervous system
/ Dendritic spines
/ Dendritic structure
/ depression
/ Depression - drug therapy
/ Depression - metabolism
/ Depression - pathology
/ Developmental plasticity
/ Dopamine receptors
/ Exercise
/ Functional plasticity
/ Genes, Tumor Suppressor
/ Glioblastoma
/ Glutamatergic transmission
/ Humans
/ Kinases
/ Mental depression
/ Mental disorders
/ MicroRNAs
/ miRNAs
/ Nervous system
/ Neural plasticity
/ Neurodegeneration
/ Neurodegenerative Diseases - metabolism
/ Neurodegenerative Diseases - pathology
/ Neurogenesis
/ Neuromodulation
/ Neuronal Plasticity - drug effects
/ Neuronal Plasticity - physiology
/ Neuroprotective Agents - pharmacology
/ Neurotransmission
/ Neurotrophic factors
/ Oncogenes
/ Paracrine signalling
/ Pathogenesis
/ Physiological effects
/ Proteins
/ Review
/ Structure-function relationships
/ Synapses
/ synaptic plasticity
/ TrkB receptors
/ γ-Aminobutyric acid
2020
Oops! Something went wrong.
While trying to remove the title from your shelf something went wrong :( Kindly try again later!
Do you wish to request the book?
Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer
by
Speranza, Luisa
, Volpicelli, Floriana
, Colucci-D'Amato, Luca
in
Alzheimer's disease
/ Animals
/ Antidepressants
/ Antidepressive Agents - pharmacology
/ Autocrine signalling
/ BDNF
/ Binding sites
/ Brain cancer
/ Brain Neoplasms - genetics
/ Brain Neoplasms - pathology
/ Brain-derived neurotrophic factor
/ Brain-Derived Neurotrophic Factor - blood
/ Brain-Derived Neurotrophic Factor - genetics
/ Brain-Derived Neurotrophic Factor - physiology
/ Central nervous system
/ Dendritic spines
/ Dendritic structure
/ depression
/ Depression - drug therapy
/ Depression - metabolism
/ Depression - pathology
/ Developmental plasticity
/ Dopamine receptors
/ Exercise
/ Functional plasticity
/ Genes, Tumor Suppressor
/ Glioblastoma
/ Glutamatergic transmission
/ Humans
/ Kinases
/ Mental depression
/ Mental disorders
/ MicroRNAs
/ miRNAs
/ Nervous system
/ Neural plasticity
/ Neurodegeneration
/ Neurodegenerative Diseases - metabolism
/ Neurodegenerative Diseases - pathology
/ Neurogenesis
/ Neuromodulation
/ Neuronal Plasticity - drug effects
/ Neuronal Plasticity - physiology
/ Neuroprotective Agents - pharmacology
/ Neurotransmission
/ Neurotrophic factors
/ Oncogenes
/ Paracrine signalling
/ Pathogenesis
/ Physiological effects
/ Proteins
/ Review
/ Structure-function relationships
/ Synapses
/ synaptic plasticity
/ TrkB receptors
/ γ-Aminobutyric acid
2020
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer
Journal Article
Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer
2020
Request now
and choose the collection method
Overview
Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin receptor kinase B (TrkB) and the low affinity p75 neurotrophin receptor (p75NTR). BDNF plays an important role in proper growth, development, and plasticity of glutamatergic and GABAergic synapses and through modulation of neuronal differentiation, it influences serotonergic and dopaminergic neurotransmission. BDNF acts as paracrine and autocrine factor, on both pre-synaptic and post-synaptic target sites. It is crucial in the transformation of synaptic activity into long-term synaptic memories. BDNF is considered an instructive mediator of functional and structural plasticity in the central nervous system (CNS), influencing dendritic spines and, at least in the hippocampus, the adult neurogenesis. Changes in the rate of adult neurogenesis and in spine density can influence several forms of learning and memory and can contribute to depression-like behaviors. The possible roles of BDNF in neuronal plasticity highlighted in this review focus on the effect of antidepressant therapies on BDNF-mediated plasticity. Moreover, we will review data that illustrate the role of BDNF as a potent protective factor that is able to confer protection against neurodegeneration, in particular in Alzheimer's disease. Finally, we will give evidence of how the involvement of BDNF in the pathogenesis of brain glioblastoma has emerged, thus opening new avenues for the treatment of this deadly cancer.
Publisher
MDPI AG,MDPI
Subject
/ Animals
/ Antidepressive Agents - pharmacology
/ BDNF
/ Brain-derived neurotrophic factor
/ Brain-Derived Neurotrophic Factor - blood
/ Brain-Derived Neurotrophic Factor - genetics
/ Brain-Derived Neurotrophic Factor - physiology
/ Exercise
/ Humans
/ Kinases
/ miRNAs
/ Neurodegenerative Diseases - metabolism
/ Neurodegenerative Diseases - pathology
/ Neuronal Plasticity - drug effects
/ Neuronal Plasticity - physiology
/ Neuroprotective Agents - pharmacology
/ Proteins
/ Review
/ Structure-function relationships
/ Synapses
This website uses cookies to ensure you get the best experience on our website.