Asset Details
Do you wish to reserve the book?
The key role of the scaffold on the efficiency of dendrimer nanodrugs
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The key role of the scaffold on the efficiency of dendrimer nanodrugs
Do you wish to request the book?
The key role of the scaffold on the efficiency of dendrimer nanodrugs
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The key role of the scaffold on the efficiency of dendrimer nanodrugs
2015
Overview
Dendrimers are well-defined macromolecules whose highly branched structure is reminiscent of many natural structures, such as trees, dendritic cells, neurons or the networks of kidneys and lungs. Nature has privileged such branched structures for increasing the efficiency of exchanges with the external medium; thus, the whole structure is of pivotal importance for these natural networks. On the contrary, it is generally believed that the properties of dendrimers are essentially related to their terminal groups, and that the internal structure plays the minor role of an 'innocent' scaffold. Here we show that such an assertion is misleading, using convergent information from biological data (human monocytes activation) and all-atom molecular dynamics simulations on seven families of dendrimers (13 compounds) that we have synthesized, possessing identical terminal groups, but different internal structures. This work demonstrates that the scaffold of nanodrugs strongly influences their properties, somewhat reminiscent of the backbone of proteins.
Publisher
Nature Publishing Group,Nature Pub. Group
Subject
/ Aza Compounds - pharmacology
/ Biocompatible Materials - chemistry
/ Biocompatible Materials - pharmacology
/ Bone Density Conservation Agents - chemistry
/ Bone Density Conservation Agents - pharmacology
/ Diphosphonates - pharmacology
/ Humans
/ Molecular Dynamics Simulation
