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Prevention of cardiovascular disease in adult recipients of kidney transplants
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Prevention of cardiovascular disease in adult recipients of kidney transplants
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Journal Article
Prevention of cardiovascular disease in adult recipients of kidney transplants
2011
Overview
Although advances in immunosuppression, tissue typing, surgery, and medical management have made transplantation a routine and preferred treatment for patients with irreversible renal failure, successful transplant recipients have a greatly increased risk of premature mortality because of cardiovascular disease and malignancy compared with the general population. Conventional cardiovascular risk factors such as hyperlipidaemia, hypertension, and diabetes are common in transplant recipients, partly because of the effects of immunosuppressive drugs, and are associated with adverse outcomes. However, the natural history of cardiovascular disease in such recipients differs from that in the general population, and only statin therapy has been studied in a large-scale interventional trial. Thus, the management of this disease and the balance between management of conventional risk factors and modification of immunosuppression is complex.
Publisher
Elsevier Ltd,Elsevier
Subject
/ adults
/ Biological and medical sciences
/ Cardiovascular Diseases - prevention & control
/ diabetes
/ Diabetes Mellitus - etiology
/ drugs
/ Dyslipidemias - drug therapy
/ Humans
/ Immunosuppressive Agents - adverse effects
/ Kidney Transplantation - adverse effects
/ patients
/ Public health. Hygiene-occupational medicine
/ risk
/ surgery
