Journal Article

Insight into the Biological Roles and Mechanisms of Phytochemicals in Different Types of Cancer: Targeting Cancer Therapeutics

Majrashi, Taghreed A., Muhsinah, Abdullatif Bin, Alshahrani, Asma M., Alrouji, Mohammad, Alshehri, Saad Ali, Atiya, Akhtar, Alsayari, Abdulrhman, Shamsi, Anas

2023

Overview

Cancer is a hard-to-treat disease with a high reoccurrence rate that affects health and lives globally. The condition has a high occurrence rate and is the second leading cause of mortality after cardiovascular disorders. Increased research and more profound knowledge of the mechanisms contributing to the disease’s onset and progression have led to drug discovery and development. Various drugs are on the market against cancer; however, the drugs face challenges of chemoresistance. The other major problem is the side effects of these drugs. Therefore, using complementary and additional medicines from natural sources is the best strategy to overcome these issues. The naturally occurring phytochemicals are a vast source of novel drugs against various ailments. The modes of action by which phytochemicals show their anti-cancer effects can be the induction of apoptosis, the onset of cell cycle arrest, kinase inhibition, and the blocking of carcinogens. This review aims to describe different phytochemicals, their classification, the role of phytochemicals as anti-cancer agents, the mode of action of phytochemicals, and their role in various types of cancer.

• Publisher: MDPI AG,MDPI
• Subject: Acids / Antineoplastic Agents - pharmacology / Antineoplastic Agents - therapeutic use / apoptosis / Cancer / Cancer therapies / Care and treatment / cell cycle checkpoints / Health aspects / Humans / Identification and classification / markets / mechanism of action / Metabolites / mortality / Neoplasms - therapy / Pharmacokinetics / Pharmacology, Experimental / Phytochemicals / Phytochemicals - pharmacology / Phytochemicals - therapeutic use / Review / therapeutics