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Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage
by
Nakao, K.
, Mori, K.
in
Acute-Phase Proteins - chemistry
/ Acute-Phase Proteins - genetics
/ Acute-Phase Proteins - metabolism
/ Acute-Phase Proteins - physiology
/ Animals
/ Biomarkers - metabolism
/ development
/ gene expression
/ Humans
/ iron
/ ischemia-reperfusion
/ Kidney - growth & development
/ Kidney Diseases - blood
/ Kidney Diseases - diagnosis
/ Kidney Diseases - metabolism
/ Kidney Diseases - urine
/ Lipocalins
/ mesenchymal-epithelial transition
/ Molecular Structure
/ progression of renal failure
/ Proto-Oncogene Proteins - chemistry
/ Proto-Oncogene Proteins - genetics
/ Proto-Oncogene Proteins - metabolism
/ Proto-Oncogene Proteins - physiology
/ Renal Insufficiency - metabolism
/ siderophore
/ Transcription, Genetic
2007
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Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage
by
Nakao, K.
, Mori, K.
in
Acute-Phase Proteins - chemistry
/ Acute-Phase Proteins - genetics
/ Acute-Phase Proteins - metabolism
/ Acute-Phase Proteins - physiology
/ Animals
/ Biomarkers - metabolism
/ development
/ gene expression
/ Humans
/ iron
/ ischemia-reperfusion
/ Kidney - growth & development
/ Kidney Diseases - blood
/ Kidney Diseases - diagnosis
/ Kidney Diseases - metabolism
/ Kidney Diseases - urine
/ Lipocalins
/ mesenchymal-epithelial transition
/ Molecular Structure
/ progression of renal failure
/ Proto-Oncogene Proteins - chemistry
/ Proto-Oncogene Proteins - genetics
/ Proto-Oncogene Proteins - metabolism
/ Proto-Oncogene Proteins - physiology
/ Renal Insufficiency - metabolism
/ siderophore
/ Transcription, Genetic
2007
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Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage
by
Nakao, K.
, Mori, K.
in
Acute-Phase Proteins - chemistry
/ Acute-Phase Proteins - genetics
/ Acute-Phase Proteins - metabolism
/ Acute-Phase Proteins - physiology
/ Animals
/ Biomarkers - metabolism
/ development
/ gene expression
/ Humans
/ iron
/ ischemia-reperfusion
/ Kidney - growth & development
/ Kidney Diseases - blood
/ Kidney Diseases - diagnosis
/ Kidney Diseases - metabolism
/ Kidney Diseases - urine
/ Lipocalins
/ mesenchymal-epithelial transition
/ Molecular Structure
/ progression of renal failure
/ Proto-Oncogene Proteins - chemistry
/ Proto-Oncogene Proteins - genetics
/ Proto-Oncogene Proteins - metabolism
/ Proto-Oncogene Proteins - physiology
/ Renal Insufficiency - metabolism
/ siderophore
/ Transcription, Genetic
2007
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Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage
Journal Article
Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage
2007
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Overview
Neutrophil gelatinase-associated lipocalin (Ngal, 24p3, SIP24, lipocalin 2, or siderocalin) was originally purified from neutrophils, but with unknown function. Recently, it was identified that Ngal activates nephron formation in the embryonic kidney, is rapidly and massively induced in renal failure and possesses kidney-protective activity. We would like to propose that blood, urine, and kidney Ngal levels are the real-time indicators of active kidney damage, rather than one of many markers of functional nephron number (as Forest Fire Theory). Ngal is a novel iron-carrier protein exerting pleiotropic actions including the upregulation of epithelial marker E-cadherin expression, opening an exciting field in cell biology.
Publisher
Elsevier Inc,Elsevier Limited
Subject
Acute-Phase Proteins - chemistry
/ Acute-Phase Proteins - genetics
/ Acute-Phase Proteins - metabolism
/ Acute-Phase Proteins - physiology
/ Animals
/ Humans
/ iron
/ Kidney - growth & development
/ Kidney Diseases - metabolism
/ mesenchymal-epithelial transition
/ progression of renal failure
/ Proto-Oncogene Proteins - chemistry
/ Proto-Oncogene Proteins - genetics
/ Proto-Oncogene Proteins - metabolism
/ Proto-Oncogene Proteins - physiology
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