Journal Article

Association between dyslipidemia and antihypertensive and antidiabetic treatments in a China multicenter study

Ji, Li‐Nong, Wang, Ji‐Guang, Miao, Chao‐Ying, Zhang, Wei, Ye, Xiao‐Fei

2021

Overview

Dyslipidemia is an emerging disease in China, especially in the presence of hypertension and diabetes mellitus. We investigated the association of dyslipidemia with the use of antihypertensive and antidiabetic agents. The study participants (n = 2423) were hypertensive and diabetic patients enrolled in a China nationwide registry. Serum mean ± (SD, except for serum triglycerides, median [interquatile range]) concentrations were 1.38 (0.97‐2.02) mmol/L, 4.85 ± 1.12 mmol/L, 1.30 ± 0.36 mmol/L, and 2.89 ± 0.92 mmol/L for triglycerides and total, high‐density lipoprotein (HDL), and low‐density lipoprotein (LDL) cholesterol, respectively. The prevalence of dyslipidemia was 18.9%, 13.5%, 16.6%, and 37.7% for hypertriglyceridemia (serum triglycerides ≥2.3 mmol/L), hypercholesterolemia (total cholesterol ≥6.2 mmol/L or LDL cholesterol ≥4.1 mmol/L), low HDL cholesterol (HDL cholesterol <1.0 mmol/L), and any of the three lipid disorders, respectively. Treated (n = 1647), compared with untreated hypertensive patients (n = 303), had a significantly (P ≤ .0006) lower serum total, LDL, and HDL cholesterol, but similar serum triglycerides (P = .20). Treated (n = 1325), compared with untreated diabetic patients (n = 238), had a significantly (P ≤ .004) lower serum triglycerides, and total and LDL cholesterol, but similar serum HDL cholesterol (P = .81). After adjustment, the odds ratios (OR) were significant for hypercholesterolemia (OR 0.76, 95% confidence interval [CI] 0.58‐0.997, P = .048) and low HDL cholesterol (OR 1.56, CI 1.19‐2.03, P = .001) in treated versus untreated hypertension, and for low HDL cholesterol (OR 1.50, CI 1.18‐1.89, P = .0008) in treated versus untreated diabetes. In conclusion, the prevalence of dyslipidemia differed between treated and untreated hypertension and diabetes. The prevalence of dyslipidemia differed between treated and untreated hypertension and diabetes mellitus in favor of treatment, in spite of some compromise in HDL cholesterol with the use of some antihypertensive or antidiabetic medications.

• Publisher: John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
• Subject: Alcohol use / Antidiabetics / Antihypertensive Agents - therapeutic use / Antihypertensives / Blood pressure / Body mass index / China - epidemiology / Cholesterol / Cholesterol, HDL - blood / Cholesterol, LDL - blood / Diabetes / diabetes mellitus / Diabetes Mellitus - drug therapy / Diabetes Mellitus - epidemiology / Diuretics / Dyslipidemia / Dyslipidemias - drug therapy / Dyslipidemias - epidemiology / Glucose / Hemoglobin / High density lipoprotein / Humans / Hypertension / Hypertension - drug therapy / Hypertension - epidemiology / Hypoglycemic Agents - therapeutic use / Lipids / Low density lipoprotein / Metabolic disorders / Original Paper / Plasma / Statins / Statistical analysis / treatment / Triglycerides / Triglycerides - blood / Variance analysis