Journal Article

Alterations of the PPP2R1B Gene in Human Lung and Colon Cancer

Huang, Liying, Wang, Steven Siqing, Evans, Glen A., Gazdar, Adi, Esplin, Edward D., Minna, John, Li, Jia Ling

1998

Overview

The PPP2R1B gene, which encodes the β isoform of the A subunit of the serine/threonine protein phosphatase 2A (PP2A), was identified as a putative human tumor suppressor gene. Sequencing of the PPP2R1B gene, located on human chromosome 11q22-24, revealed somatic alterations in 15% (5 out of 33) of primary lung tumors, 6% (4 out of 70) of lung tumor-derived cell lines, and 15% (2 out of 13) of primary colon tumors. One deletion mutation generated a truncated PP2A-Aβ protein that was unable to bind to the catalytic subunit of the PP2A holoenzyme. The PP2R1B gene product may suppress tumor development through its role in cell cycle regulation and cellular growth control.

• Publisher: American Society for the Advancement of Science,American Association for the Advancement of Science,The American Association for the Advancement of Science
• Subject: Alleles / Amino Acid Sequence / Biological and medical sciences / Cancer / Cancer research / Cell Cycle / Cell Division / Cell lines / Chromosome Mapping / Chromosomes / Chromosomes, Human, Pair 11 - genetics / Coding / Colonic Neoplasms - enzymology / Colonic Neoplasms - genetics / Colorectal cancer / Frameshift Mutation / Gastroenterology. Liver. Pancreas. Abdomen / Genes / Genes, Tumor Suppressor / Genetic research / Humans / Loss of Heterozygosity / Lung cancer / Lung Neoplasms - enzymology / Lung Neoplasms - genetics / Lungs / Medical sciences / Molecular Sequence Data / Phosphoprotein Phosphatases - chemistry / Phosphoprotein Phosphatases - genetics / Phosphoprotein Phosphatases - metabolism / Point Mutation / Polymerase chain reaction / Protein Phosphatase 2 / Sequence Deletion / Sequencing / Stomach. Duodenum. Small intestine. Colon. Rectum. Anus / Tumor cell line / Tumor Cells, Cultured / Tumors