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Potential mechanisms of resistance to TRAIL/Apo2L-induced apoptosis in human promyelocytic leukemia HL-60 cells during granulocytic differentiation
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Potential mechanisms of resistance to TRAIL/Apo2L-induced apoptosis in human promyelocytic leukemia HL-60 cells during granulocytic differentiation
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Potential mechanisms of resistance to TRAIL/Apo2L-induced apoptosis in human promyelocytic leukemia HL-60 cells during granulocytic differentiation
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Journal Article
Potential mechanisms of resistance to TRAIL/Apo2L-induced apoptosis in human promyelocytic leukemia HL-60 cells during granulocytic differentiation
2000
Overview
Human promyelocytic leukemia HL-60 cells are well known to differentiate into granulocytes or monocytes in the presence of some agents such as DMSO or PMA, respectively. Differentiated HL-60 cells become resistant to some apoptotic stimuli including anticancer drugs or irradiation though undifferentiated cells significantly respond to these stimuli. TRAIL (TNF-related apoptosis-inducing ligand) which is also known as Apo2 ligand (Apo2L), a new member of TNF family, can induce apoptosis in some tumor cells but not in many normal cells. We show here that apoptosis is well induced in HL-60 cells by TRAIL, but susceptibility to TRAIL is reduced during granulocytic differentiation by DMSO. We also suggest some possible mechanisms by which granulocytic differentiated cells become resistant to TRAIL-induced apoptosis. First, in granulocytic differentiated cells, expression of antagonistic decoy receptors for TRAIL (TRAIL-R3/TRID/DcR1/LIT and TRAIL-R4/TRUNDD/DcR2) were enhanced. In addition, expression of Toso, a cell surface apoptosis regulator, seemed to block activation of caspase-8 by TRAIL via enhanced expression of FLIPL in granulocytic differentiated cells. These findings suggest that differentiated cells are resistant using plural mechanisms against various apoptosis-inducing stimuli rather than undifferentiated cells.
Publisher
Springer Science and Business Media LLC,Nature Publishing Group
Subject
/ Apoptosis Regulatory Proteins
/ Cancer
/ Carrier Proteins - metabolism
/ CASP8 and FADD-Like Apoptosis Regulating Protein
/ Caspases
/ Cell Differentiation - immunology
/ Gene Expression - physiology
/ Humans
/ Intracellular Signaling Peptides and Proteins
/ Leukemia
/ Ligands
/ Membrane Glycoproteins - genetics
/ Membrane Glycoproteins - metabolism
/ Membrane Proteins - genetics
/ Membrane Proteins - metabolism
/ Proteins
/ Receptors, Tumor Necrosis Factor
/ Receptors, Tumor Necrosis Factor - genetics
/ Receptors, Tumor Necrosis Factor - metabolism
/ Receptors, Tumor Necrosis Factor, Member 10c
/ TNF-Related Apoptosis-Inducing Ligand
/ Tumor Necrosis Factor Decoy Receptors
/ Tumor Necrosis Factor-alpha - genetics
