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Crosstalk between the gut microbiota and brain network topology in poststroke aphasia patients: perspectives from neuroimaging findings
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Crosstalk between the gut microbiota and brain network topology in poststroke aphasia patients: perspectives from neuroimaging findings
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Journal Article
Crosstalk between the gut microbiota and brain network topology in poststroke aphasia patients: perspectives from neuroimaging findings
2025
Overview
Plain language summary
Alterations in the gut microbiota may influence language recovery in patients with poststroke aphasia
Aphasia is one of the most common complications of stroke, affecting approximately one-third of stroke survivors. Poststroke aphasia (PSA) is associated with more severe strokes, higher mortality, slower functional recovery, and greater healthcare costs compared to stroke patients without PSA. The unique characteristics of human language, which cannot be fully replicated in animal models, present a significant barrier to exploring the pathogenesis of PSA. Consequently, understanding the underlying neural pathways and identifying novel therapeutic targets is critically important. Recent evidence highlights the bidirectional communication between the gut microbiota and the brain, referred to as the microbiota-gut-brain axis. Our prior studies have demonstrated gut microbiota imbalances in patients with acute ischemic stroke, which significantly influence outcomes and prognosis. Considering the marked differences in disease severity and long-term prognosis between PSA patients and non-PSA patients, we hypothesized that variations in the microbiota-gut-brain axis might be linked to language function. To test this hypothesis, we employed functional magnetic resonance imaging (fMRI), 16S rDNA sequencing and enzyme-linked immunosorbent assay (ELISA) to explore differences in gut microbiota composition, neuroendocrine-immune network (NEI) network indicators, and brain network topology among PSA patients, non-PSA patients, and healthy controls (HCs). Our findings revealed that PSA patients, compared to non-PSA patients and HCs, exhibited gut microbiota dysbiosis, increased inflammatory responses, abnormal secretion of brain-gut peptides, and early activation of homologous language-related regions in the right hemisphere. These results provide new insights into the role of the gut microbiota in language recovery in PSA and highlight the gut microbiota as a promising therapeutic target for this condition.
Publisher
SAGE Publications,SAGE Publishing
