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NY-ESO-1 (CTAG1B) expression in mesenchymal tumors

by Ingram, Davis R , Briaire-de Bruijn, Inge H , Lev, Dina C , Somaiah, Neeta , Bovée, Judith VMG , Endo, Makoto , Lim, Simin , de Graaff, Marieke A , Lazar, Alexander J , Nielsen, Torsten O

in 13/51 / 631/67/1798 / 692/308/1892 / 692/699/67/1798 / Antigens, Neoplasm - metabolism / Bone Neoplasms - metabolism / Bone Neoplasms - pathology / Humans / Laboratory Medicine / Medicine / Medicine & Public Health / Membrane Proteins - metabolism / original-article / Pathology / Sarcoma - metabolism / Sarcoma - pathology / Soft Tissue Neoplasms - metabolism / Soft Tissue Neoplasms - pathology / Tissue Array Analysis

2015

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NY-ESO-1 (CTAG1B) expression in mesenchymal tumors

by Ingram, Davis R , Briaire-de Bruijn, Inge H , Lev, Dina C , Somaiah, Neeta , Bovée, Judith VMG , Endo, Makoto , Lim, Simin , de Graaff, Marieke A , Lazar, Alexander J , Nielsen, Torsten O

2015

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NY-ESO-1 (CTAG1B) expression in mesenchymal tumors

by Ingram, Davis R , Briaire-de Bruijn, Inge H , Lev, Dina C , Somaiah, Neeta , Bovée, Judith VMG , Endo, Makoto , Lim, Simin , de Graaff, Marieke A , Lazar, Alexander J , Nielsen, Torsten O

2015

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Journal Article

NY-ESO-1 (CTAG1B) expression in mesenchymal tumors

Ingram, Davis R,

Briaire-de Bruijn, Inge H,

Lev, Dina C,

Somaiah, Neeta,

Bovée, Judith VMG,

Endo, Makoto,

Lim, Simin,

de Graaff, Marieke A,

Lazar, Alexander J,

Nielsen, Torsten O

2015

Overview

New York esophageal squamous cell carcinoma 1 (NY-ESO-1, CTAG1B) is a cancer-testis antigen and currently a focus of several targeted immunotherapeutic strategies. We performed a large-scale immunohistochemical expression study of NY-ESO-1 using tissue microarrays of mesenchymal tumors from three institutions in an international collaboration. A total of 1132 intermediate and malignant and 175 benign mesenchymal lesions were enrolled in this study. Immunohistochemical staining was performed on tissue microarrays using a monoclonal antibody for NY-ESO-1. Among mesenchymal tumors, myxoid liposarcomas showed the highest positivity for NY-ESO-1 (88%), followed by synovial sarcomas (49%), myxofibrosarcomas (35%), and conventional chondrosarcomas (28%). Positivity of NY-ESO-1 in the remaining mesenchymal tumors was consistently low, and no immunoreactivity was observed in benign mesenchymal lesions. On the basis of these findings, nearly 90% of myxoid liposarcomas, as well as a significant proportion of synovial sarcomas, myxofibrosarcomas, and conventional chondrosarcomas are good candidates for immunotherapy targeting NY-ESO-1.

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Publisher

Nature Publishing Group US,Elsevier Limited

Subject

/ Antigens, Neoplasm - metabolism

/ Bone Neoplasms - metabolism

/ Bone Neoplasms - pathology