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Adenovirus-vectored PDCoV vaccines induce potent humoral and cellular immune responses in mice

by Zhang, Zhongwang , Pan, Li , Yu, Ruiming , Wang, Yonglu , Miao, Xin , Guo, Huichen , Zhang, Liping , Liu, Xinsheng , Zhou, Peng , Wang, Cancan

in Ad5-vector vaccine / Adenoviruses / Allergy and Immunology / Antibodies / Cell culture / Coronaviruses / Dehydration / Diarrhea / Disease transmission / Economic impact / enteropathogens / Genomes / Glycoproteins / Hogs / Human mastadenovirus C / Immune response / Immune response (cell-mediated) / Immune response (humoral) / Immunization / Immunogenicity / industry / Laboratory animals / Membranes / Microscopy / mortality / Mucosal immunity / Oral / oral gavage / PDCoV / Peptides / Plasmids / Porcine deltacoronaviruses / Protein expression / Proteins / R&D / Research & development / Robustness / Spike glycoprotein / swine / Thrombolytic drugs / Vaccine development / Vaccines / Viruses / Vomiting

2023

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Adenovirus-vectored PDCoV vaccines induce potent humoral and cellular immune responses in mice

by Zhang, Zhongwang , Pan, Li , Yu, Ruiming , Wang, Yonglu , Miao, Xin , Guo, Huichen , Zhang, Liping , Liu, Xinsheng , Zhou, Peng , Wang, Cancan

2023

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Adenovirus-vectored PDCoV vaccines induce potent humoral and cellular immune responses in mice

by Zhang, Zhongwang , Pan, Li , Yu, Ruiming , Wang, Yonglu , Miao, Xin , Guo, Huichen , Zhang, Liping , Liu, Xinsheng , Zhou, Peng , Wang, Cancan

2023

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Journal Article

Adenovirus-vectored PDCoV vaccines induce potent humoral and cellular immune responses in mice

Zhang, Zhongwang,

Pan, Li,

Yu, Ruiming,

Wang, Yonglu,

Miao, Xin,

Guo, Huichen,

Zhang, Liping,

Liu, Xinsheng,

Zhou, Peng,

Wang, Cancan

2023

Overview

Porcine deltacoronavirus (PDCoV) is a novel swine enteropathogenic coronavirus that causes severe watery diarrhea, vomiting, dehydration and high mortality in piglets, resulting in significant economic losses by the global pig industry. Recently, PDCoV has also shown the potential for cross-species transmission. However, there are currently few vaccine studies and no commercially available vaccines for PDCoV. Hence, here, two novel human adenovirus 5 (Ad5)-vectored vaccines expressing codon-optimized forms of the PDCoV spike (S) glycoprotein (Ad-PD-tPA-Sopt) and S1 glycoprotein (Ad-PD-oriSIP-S1opt) were constructed, and their effects were evaluated via intramuscular (IM) injection in BALB/c mice with different doses and times. Both vaccines elicited robust humoral and cellular immune responses; moreover, Ad-PD-tPA-Sopt-vaccinated mice after two IM injections with 108 infectious units (IFU)/mouse had significantly higher anti-PDCoV-specific neutralizing antibody titers. In contrast, the mice immunized with Ad-PD-tPA-Sopt via oral gavage (OG) did not generate robust systemic and mucosal immunity. Thus, IM Ad-PD-tPA-Sopt administration is a promising strategy against PDCoV and provides useful information for future animal vaccine development.

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Publisher

Elsevier Ltd,Elsevier Limited

Subject

Ad5-vector vaccine

/ Adenoviruses

/ Allergy and Immunology