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Development of a Proton-Enhanced ESI UPLC-MS/MS Method for the Determination of Tetrodotoxin
by
Li, Tong
, Wang, Ruiguo
, Wang, Peilong
in
Acids
/ Animals
/ Chromatography
/ Chromatography, Liquid - methods
/ Fish
/ Food contamination & poisoning
/ Ionization
/ Lipids
/ Marine toxins
/ Mass spectrometry
/ Methods
/ Neurotoxins
/ Optimization
/ proton-enhanced
/ Protons
/ puffer fish
/ Reagents
/ Scientific imaging
/ Seafood
/ Solvents
/ Tandem Mass Spectrometry - methods
/ Tetraodontiformes
/ tetrodotoxin
/ Tetrodotoxin - analysis
/ Tetrodotoxin - chemistry
/ UPLC-MS/MS
2022
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Development of a Proton-Enhanced ESI UPLC-MS/MS Method for the Determination of Tetrodotoxin
by
Li, Tong
, Wang, Ruiguo
, Wang, Peilong
in
Acids
/ Animals
/ Chromatography
/ Chromatography, Liquid - methods
/ Fish
/ Food contamination & poisoning
/ Ionization
/ Lipids
/ Marine toxins
/ Mass spectrometry
/ Methods
/ Neurotoxins
/ Optimization
/ proton-enhanced
/ Protons
/ puffer fish
/ Reagents
/ Scientific imaging
/ Seafood
/ Solvents
/ Tandem Mass Spectrometry - methods
/ Tetraodontiformes
/ tetrodotoxin
/ Tetrodotoxin - analysis
/ Tetrodotoxin - chemistry
/ UPLC-MS/MS
2022
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Development of a Proton-Enhanced ESI UPLC-MS/MS Method for the Determination of Tetrodotoxin
by
Li, Tong
, Wang, Ruiguo
, Wang, Peilong
in
Acids
/ Animals
/ Chromatography
/ Chromatography, Liquid - methods
/ Fish
/ Food contamination & poisoning
/ Ionization
/ Lipids
/ Marine toxins
/ Mass spectrometry
/ Methods
/ Neurotoxins
/ Optimization
/ proton-enhanced
/ Protons
/ puffer fish
/ Reagents
/ Scientific imaging
/ Seafood
/ Solvents
/ Tandem Mass Spectrometry - methods
/ Tetraodontiformes
/ tetrodotoxin
/ Tetrodotoxin - analysis
/ Tetrodotoxin - chemistry
/ UPLC-MS/MS
2022
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Development of a Proton-Enhanced ESI UPLC-MS/MS Method for the Determination of Tetrodotoxin
Journal Article
Development of a Proton-Enhanced ESI UPLC-MS/MS Method for the Determination of Tetrodotoxin
2022
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Overview
Tetrodotoxin (TTX) is a kind of low-molecular-weight non-protein neurotoxin. It is one of the most potent neurotoxins found in nature, and it is found in puffer fish and various marine biota. The low sensitivity of previous analytical methods limited their application in puffer fish organ samples. This study established a method for the accurate and fast determination of TTX by reversed ultra-performance liquid chromatography coupled with proton-enhanced electron spray ionization–tandem mass spectrometry. The method yields good peak shapes, high sensitivity and low coeluted interferences. The method was successfully applied to determine TTX in puffer fish tissue samples of about 0.2 g.
Publisher
MDPI AG,MDPI
Subject
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