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Breakthrough Invasive Fungal Infection After Coadministration of Venetoclax and Voriconazole
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Breakthrough Invasive Fungal Infection After Coadministration of Venetoclax and Voriconazole
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Journal Article
Breakthrough Invasive Fungal Infection After Coadministration of Venetoclax and Voriconazole
2023
Overview
Abstract
Venetoclax requires a 75% dose reduction when coadministered with voriconazole. In a 10-year historical cohort of treatment with venetoclax, we did not observe a worse hematologic outcome in patients who received voriconazole prophylaxis versus those who did not. Subtherapeutic voriconazole levels and a triazole exposure history may contribute to breakthrough invasive fungal infection.
Publisher
Oxford University Press
Subject
