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NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases
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NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases
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Journal Article
NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases
2020
Overview
NRF2 acts by controlling gene expression, being the master regulator of the Phase II antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity is regulated at several levels, including protein degradation by the proteasome, transcription, and post-transcription. The purpose of this review is to offer a concise and critical overview of the main mechanisms of NRF2 regulation and their actual or potential use as targets for the treatment of neurodegenerative diseases.
Publisher
MDPI AG,MDPI
Subject
/ Central Nervous System Agents - isolation & purification
/ Central Nervous System Agents - therapeutic use
/ Gene Expression Regulation - drug effects
/ Humans
/ KEAP1
/ Molecular Targeted Therapy - methods
/ Neurodegenerative Diseases - drug therapy
/ Neurodegenerative Diseases - genetics
/ Neurodegenerative Diseases - metabolism
/ NF-E2-Related Factor 2 - antagonists & inhibitors
/ NF-E2-Related Factor 2 - drug effects
/ NF-E2-Related Factor 2 - genetics
/ NF-E2-Related Factor 2 - metabolism
/ Review
