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Redox Signaling from Mitochondria: Signal Propagation and Its Targets
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Redox Signaling from Mitochondria: Signal Propagation and Its Targets
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Journal Article
Redox Signaling from Mitochondria: Signal Propagation and Its Targets
2020
Overview
Progress in mass spectroscopy of posttranslational oxidative modifications has enabled researchers to experimentally verify the concept of redox signaling. We focus here on redox signaling originating from mitochondria under physiological situations, discussing mechanisms of transient redox burst in mitochondria, as well as the possible ways to transfer such redox signals to specific extramitochondrial targets. A role of peroxiredoxins is described which enables redox relay to other targets. Examples of mitochondrial redox signaling are discussed: initiation of hypoxia-inducible factor (HIF) responses; retrograde redox signaling to PGC1α during exercise in skeletal muscle; redox signaling in innate immune cells; redox stimulation of insulin secretion, and other physiological situations.
Publisher
MDPI AG,MDPI
Subject
/ hif
/ Hydrogen Peroxide - metabolism
/ Hypoxia
/ Insulin
/ Insulin-Secreting Cells - metabolism
/ Kinases
/ mitochondrial superoxide formation
/ Muscle, Skeletal - metabolism
/ Protein Processing, Post-Translational
/ Proteins
/ Reactive Oxygen Species - metabolism
/ redox signaling from mitochondria
/ Review
