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Non-genetic mechanisms of diabetic nephropathy
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Journal Article
Non-genetic mechanisms of diabetic nephropathy
2017
Overview
Diabetic nephropathy （DN） is one of the most common microvascular complications in diabetes mellitus patients and is characterized by thickened glomeruIar basement membrane, increased extracellular matrix formation, and podocyte loss. These phenomena lead to proteinuria and altered glomerular filtration rate, that is, the rate initially increases but progressively decreases. DN has become the leading cause of end-stage renal disease. Its prevalence shows a rapid growth trend and causes heavy social and economic burden in many countries. However, this disease is multifactorial, and its mechanism is poorly understood due to the complex pathogenesis of DN. In this review, we highlight the new molecular insights about the pathogenesis of DN from the aspects of immune inflammation response, epithelial-mesenchymal transition, apoptosis and mitochondrial damage, epigenetics, and podocyte-endothelial communication. This work offers groundwork for understanding the initiation and progression of DN, as well as provides ideas for developing new prevention and treatment measures.
Publisher
Higher Education Press,Springer Nature B.V
Subject
/ Diabetes
/ Diabetic Nephropathies - complications
/ Diabetic Nephropathies - immunology
/ Diabetic Nephropathies - physiopathology
/ Epithelial-Mesenchymal Transition
/ Humans
/ immune inflammatory response
/ Kidney Failure, Chronic - etiology
/ Medicine
/ podocyte-endothelial communication
/ Review
/ 发病机制
/ 炎症反应
/ 糖尿病肾病
/ 细胞外基质
/ 肾小球滤过率
/ 肾脏疾病
/ 表观遗传学
/ 遗传机制
