Journal Article

Outcome of patients with HIV-related germ cell tumours: a case–control study

Shamash, J, Nelson, M, Ong, J, De Ruiter, A, Oliver, T, Powles, T, Johnson, M, Anderson, J, Fisher, M, Stebbing, J, Bower, M, Daugaard, G, Gazzard, B

2004

Overview

Testicular germ cell tumour (GCT) is not an AIDS-defining illness despite an increased incidence in men with HIV infection. We performed a matched case-control study comparing outcomes in HIV-positive men and the general population with GCT, using three age and stage matched controls for each case. There was no difference in the 5-year GCT-free survival between cases and controls. However, overall survival was significantly decreased in the cases (log rank P =0.03). HIV was responsible for 70% of this mortality. The relapse-free survival for stage I patients treated with orchidectomy and surveillance was not affected by HIV status (log rank P =0.68). There was no difference in disease free survival in patients with metastatic disease (log rank P =0.78). The overall survival has not improved since the introduction of highly active antiretroviral therapy (log rank P =0.4). Thus, HIV-related GCT is not more aggressive than GCT in the general population.

• Publisher: Nature Publishing Group UK,Nature Publishing Group
• Subject: Adult / Biological and medical sciences / Biomedical and Life Sciences / Biomedicine / Cancer Research / Case-Control Studies / Clinical / Disease-Free Survival / Drug Resistance / Epidemiology / Germinoma - pathology / Germinoma - surgery / Germinoma - virology / HIV Infections - complications / Human immunodeficiency virus / Human viral diseases / Humans / Infectious diseases / Male / Medical sciences / Middle Aged / Molecular Medicine / Neoplasm Staging / Oncology / Orchiectomy / Prognosis / Testicular Neoplasms - pathology / Testicular Neoplasms - surgery / Testicular Neoplasms - virology / Viral diseases / Viral diseases of the lymphoid tissue and the blood. Aids