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Pan-cancer characterization of expression and clinical relevance of m6A-related tissue-elevated long non-coding RNAs
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Pan-cancer characterization of expression and clinical relevance of m6A-related tissue-elevated long non-coding RNAs
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Pan-cancer characterization of expression and clinical relevance of m6A-related tissue-elevated long non-coding RNAs
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Journal Article
Pan-cancer characterization of expression and clinical relevance of m6A-related tissue-elevated long non-coding RNAs
2021
Overview
TE lncRNAs are associated with m6A modification across tissues We first retrieved the TE lncRNAs from 38 normal tissues from LncSpA in 4 data resources (Fig. 1a), including Human Body Map (HBM2.0), Human Protein Atlas (HPA), the Genotype-Tissue Expression (GTEx), and the Function Annotation Of The Mammalian Genome (FANTOM) project. The extent to which variation in m6A modification of TE lncRNAs may be attributed to the expression of m6A regulators remains unknown. [...]we next sought to analyze the correlation between the expressions of m6A-modified TE lncRNAs and regulators. Table S4). [...]we identified 28 m6A-modified TE lncRNAs that had significantly higher expression in cancer patients than in healthy controls and 8 m6A-modified TE lncRNAs that had significantly lower expression (Fig. 2a and Additional file 5: Several studies have also shown that m6Am can regulate the expression of noncoding RNAs. [...]it would also be interesting to integrate such m6A and m6Am data to identify potential lncRNA biomarkers in cancer.
