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Radioresistance in Glioblastoma and the Development of Radiosensitizers

by Allen, Bryan G. , Spitz, Douglas R. , Noman, Abu Shadat M. , Oliva, Claudia R. , Buatti, John M. , Ali, Md Yousuf , Griguer, Corinne E. , Goswami, Prabhat C. , Zakharia, Yousef , Monga, Varun

in Brain cancer / Chemotherapy / Clinical trials / Drug resistance / Drug therapy / Glioblastoma / Glioblastomas / Ionizing radiation / Magnetic resonance imaging / Medical prognosis / Metabolism / Metabolites / Observations / Patient outcomes / Patients / Radiation therapy / Radioresistance / Radiosensitizers / Radiotherapy / Review / Spectrum analysis / Surgery / Tumors / X-rays

2020

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Radioresistance in Glioblastoma and the Development of Radiosensitizers

by Allen, Bryan G. , Spitz, Douglas R. , Noman, Abu Shadat M. , Oliva, Claudia R. , Buatti, John M. , Ali, Md Yousuf , Griguer, Corinne E. , Goswami, Prabhat C. , Zakharia, Yousef , Monga, Varun

2020

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Radioresistance in Glioblastoma and the Development of Radiosensitizers

by Allen, Bryan G. , Spitz, Douglas R. , Noman, Abu Shadat M. , Oliva, Claudia R. , Buatti, John M. , Ali, Md Yousuf , Griguer, Corinne E. , Goswami, Prabhat C. , Zakharia, Yousef , Monga, Varun

2020

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Journal Article

Radioresistance in Glioblastoma and the Development of Radiosensitizers

Allen, Bryan G.,

Spitz, Douglas R.,

Noman, Abu Shadat M.,

Oliva, Claudia R.,

Buatti, John M.,

Ali, Md Yousuf,

Griguer, Corinne E.,

Goswami, Prabhat C.,

Zakharia, Yousef,

Monga, Varun

2020

Overview

Ionizing radiation is a common and effective therapeutic option for the treatment of glioblastoma (GBM). Unfortunately, some GBMs are relatively radioresistant and patients have worse outcomes after radiation treatment. The mechanisms underlying intrinsic radioresistance in GBM has been rigorously investigated over the past several years, but the complex interaction of the cellular molecules and signaling pathways involved in radioresistance remains incompletely defined. A clinically effective radiosensitizer that overcomes radioresistance has yet to be identified. In this review, we discuss the current status of radiation treatment in GBM, including advances in imaging techniques that have facilitated more accurate diagnosis, and the identified mechanisms of GBM radioresistance. In addition, we provide a summary of the candidate GBM radiosensitizers being investigated, including an update of subjects enrolled in clinical trials. Overall, this review highlights the importance of understanding the mechanisms of GBM radioresistance to facilitate the development of effective radiosensitizers.

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MDPI AG,MDPI

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