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PEG-coated gold nanoparticles attenuate β-adrenergic receptor-mediated cardiac hypertrophy
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PEG-coated gold nanoparticles attenuate β-adrenergic receptor-mediated cardiac hypertrophy
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Journal Article
PEG-coated gold nanoparticles attenuate β-adrenergic receptor-mediated cardiac hypertrophy
2017
Overview
Gold nanoparticles (AuNPs) are widely used as a drug delivery vehicle, which can accumulate in the heart through blood circulation. Therefore, it is very important to understand the effect of AuNPs on the heart, especially under pathological conditions. In this study, we found that PEG-coated AuNPs attenuate β-adrenergic receptor (β-AR)-mediated acute cardiac hypertrophy and inflammation. However, both isoproterenol, a non-selective β-AR agonist, and AuNPs did not induce cardiac function change or cardiac fibrosis. AuNPs exerted an anti-cardiac hypertrophy effect by decreasing β
-AR expression and its downstream ERK1/2 hypertrophic pathway. Our results indicated that AuNPs might be safe and have the potential to be used as multi-functional materials (drug carrier systems and anti-cardiac hypertrophy agents).
Publisher
Taylor & Francis Ltd,Dove Press,Dove Medical Press
Subject
Adrenergic beta-Agonists - pharmacology
/ Adrenergic beta-Agonists - toxicity
/ Animals
/ AuNPs
/ Diabetes
/ Fibrosis - chemically induced
/ Kinases
/ Male
/ MAP Kinase Signaling System - drug effects
/ Nanoparticles - administration & dosage
/ Polyethylene Glycols - chemistry
/ Proteins
/ Receptors, Adrenergic, beta - genetics
/ Receptors, Adrenergic, beta - metabolism
/ Receptors, Adrenergic, beta-1 - metabolism
/ Studies
