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Protrusion-derived vesicles: new subtype of EVs?
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Protrusion-derived vesicles: new subtype of EVs?
Protrusion-derived vesicles: new subtype of EVs?
Journal Article

Protrusion-derived vesicles: new subtype of EVs?

2023
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Overview
Cellular protrusions are highly dynamic structures that facilitate cell–cell communication and are increasingly recognised for their roles in the shedding of bioactive extracellular vesicles (EVs). The intrinsic and extrinsic mechanisms that govern the shedding of EVs from cellular protrusions and their potential physiological roles are beginning to emerge.This Comment draws attention to cellular protrusions as a source of extracellular vesicles (EVs). These protrusion-derived vesicles expand the repertoire of EVs, impacting current nomenclature and our understanding of EV functions in inter-cellular communication.