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Comparative genomic analysis of Lactobacillus plantarum ZJ316 reveals its genetic adaptation and potential probiotic profiles
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Comparative genomic analysis of Lactobacillus plantarum ZJ316 reveals its genetic adaptation and potential probiotic profiles
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Journal Article
Comparative genomic analysis of Lactobacillus plantarum ZJ316 reveals its genetic adaptation and potential probiotic profiles
2016
Overview
Objective
In previous studies,
Lactobacillus plantarum
ZJ316 showed probiotic properties, such as antimicrobial activity against various pathogens and the capacity to significantly improve pig growth and pork quality. The purpose of this study was to reveal the genes potentially related to its genetic adaptation and probiotic profiles based on comparative genomic analysis.
Methods
The genome sequence of
L. plantarum
ZJ316 was compared with those of eight
L. plantarum
strains deposited in GenBank. BLASTN, Mauve, and MUMmer programs were used for genome alignment and comparison. CRISPRFinder was applied for searching the clustered regularly interspaced short palindromic repeats (CRISPRs).
Results
We identified genes that encode proteins related to genetic adaptation and probiotic profiles, including carbohydrate transport and metabolism, proteolytic enzyme systems and amino acid biosynthesis, CRISPR adaptive immunity, stress responses, bile salt resistance, ability to adhere to the host intestinal wall, exopolysaccharide (EPS) biosynthesis, and bacteriocin biosynthesis.
Conclusions
Comparative characterization of the
L. plantarum
ZJ316 genome provided the genetic basis for further elucidating the functional mechanisms of its probiotic properties. ZJ316 could be considered a potential probiotic candidate.
Publisher
Zhejiang University Press,Springer Nature B.V
Subject
/ Bacterial Capsules - metabolism
/ Bile
/ Biomedical and Life Sciences
/ China
/ Clustered Regularly Interspaced Short Palindromic Repeats
/ CRISPR
/ Genes
/ Genomes
/ genomics
/ Immunity
/ Lactobacillus plantarum - classification
/ Lactobacillus plantarum - genetics
/ Pork
/ Proteins
/ Salts
/ swine
/ Yogurt
