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Concise Review: Fat and Furious: Harnessing the Full Potential of Adipose‐Derived Stromal Vascular Fraction
by
Patrick, Ryan J.
, Weimer, Jill M.
, Kota, Daniel J.
, Dykstra, Jordan A.
, Milanovich, Samuel
, Facile, Tiffany
, Francis, Kevin R.
in
Adipocytes - cytology
/ Adipose
/ Adipose Tissue - cytology
/ Adult stem cells
/ Alzheimer's disease
/ Angina pectoris
/ Animals
/ Autologous stem cell transplantation
/ Blood
/ Bone marrow
/ Cellular therapy
/ Clinical trials
/ Congestive heart failure
/ Coronary artery disease
/ Diabetes mellitus
/ Humans
/ Labeling
/ Mesenchymal stem cells
/ Mesenchymal Stem Cells - cytology
/ Neurodegenerative diseases
/ Paracrine signalling
/ Regenerative medicine
/ Regenerative Medicine - methods
/ Stem Cell Transplantation
/ Stem cells
/ Stem Cells - cytology
/ Studies
/ Therapeutic applications
/ Tissue‐Specific Progenitor and Stem Cells
/ Translational s and Reviews
/ Writing
2017
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Concise Review: Fat and Furious: Harnessing the Full Potential of Adipose‐Derived Stromal Vascular Fraction
by
Patrick, Ryan J.
, Weimer, Jill M.
, Kota, Daniel J.
, Dykstra, Jordan A.
, Milanovich, Samuel
, Facile, Tiffany
, Francis, Kevin R.
in
Adipocytes - cytology
/ Adipose
/ Adipose Tissue - cytology
/ Adult stem cells
/ Alzheimer's disease
/ Angina pectoris
/ Animals
/ Autologous stem cell transplantation
/ Blood
/ Bone marrow
/ Cellular therapy
/ Clinical trials
/ Congestive heart failure
/ Coronary artery disease
/ Diabetes mellitus
/ Humans
/ Labeling
/ Mesenchymal stem cells
/ Mesenchymal Stem Cells - cytology
/ Neurodegenerative diseases
/ Paracrine signalling
/ Regenerative medicine
/ Regenerative Medicine - methods
/ Stem Cell Transplantation
/ Stem cells
/ Stem Cells - cytology
/ Studies
/ Therapeutic applications
/ Tissue‐Specific Progenitor and Stem Cells
/ Translational s and Reviews
/ Writing
2017
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Concise Review: Fat and Furious: Harnessing the Full Potential of Adipose‐Derived Stromal Vascular Fraction
by
Patrick, Ryan J.
, Weimer, Jill M.
, Kota, Daniel J.
, Dykstra, Jordan A.
, Milanovich, Samuel
, Facile, Tiffany
, Francis, Kevin R.
in
Adipocytes - cytology
/ Adipose
/ Adipose Tissue - cytology
/ Adult stem cells
/ Alzheimer's disease
/ Angina pectoris
/ Animals
/ Autologous stem cell transplantation
/ Blood
/ Bone marrow
/ Cellular therapy
/ Clinical trials
/ Congestive heart failure
/ Coronary artery disease
/ Diabetes mellitus
/ Humans
/ Labeling
/ Mesenchymal stem cells
/ Mesenchymal Stem Cells - cytology
/ Neurodegenerative diseases
/ Paracrine signalling
/ Regenerative medicine
/ Regenerative Medicine - methods
/ Stem Cell Transplantation
/ Stem cells
/ Stem Cells - cytology
/ Studies
/ Therapeutic applications
/ Tissue‐Specific Progenitor and Stem Cells
/ Translational s and Reviews
/ Writing
2017
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Concise Review: Fat and Furious: Harnessing the Full Potential of Adipose‐Derived Stromal Vascular Fraction
Journal Article
Concise Review: Fat and Furious: Harnessing the Full Potential of Adipose‐Derived Stromal Vascular Fraction
2017
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Overview
Due to their capacity to self‐renew, proliferate and generate multi‐lineage cells, adult‐derived stem cells offer great potential for use in regenerative therapies to stop and/or reverse degenerative diseases such as diabetes, heart failure, Alzheimer's disease and others. However, these subsets of cells can be isolated from different niches, each with differing potential for therapeutic applications. The stromal vascular fraction (SVF), a stem cell enriched and adipose‐derived cell population, has garnered interest as a therapeutic in regenerative medicine due to its ability to secrete paracrine factors that accelerate endogenous repair, ease of accessibility and lack of identified major adverse effects. Thus, one can easily understand the rush to employ adipose‐derived SVF to treat human disease. Perhaps faster than any other cell preparation, SVF is making its way to clinics worldwide, while critical preclinical research needed to establish SVF safety, efficacy and optimal, standardized clinical procedures are underway. Here, we will provide an overview of the current knowledge driving this phenomenon, its regulatory issues and existing studies, and propose potential unmapped applications. Stem Cells Translational Medicine 2017;6:1096–1108
Publisher
Oxford University Press,John Wiley and Sons Inc
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