Journal Article

Roles of FGF8 subfamily in embryogenesis and oral-maxillofacial diseases (Review)

Liu, Rui, Hao, Yilong, Tang, Shuya, Yuan, Yao, Chen, Qianming

2019

Overview

Fibroblast growth factors (FGFs) are diffusible polypeptides released by a variety of cell types. FGF8 subfamily members regulate embryonic development processes through controlling progenitor cell growth and differentiation, and are also functional in adults in tissue repair to maintain tissue homeostasis. FGF8 family members exhibit unique binding affinities with FGF receptors and tissue distribution patterns. Increasing evidence suggests that, by regulating multiple cellular signaling pathways, alterations in the FGF8 subfamily are involved in craniofacial development, odontogenesis, tongue development and salivary gland branching morphogenesis. Aberrant FGF signaling transduction, caused by mutations as well as abnormal expression or isoform splicing, plays an important role in the development of oral diseases. Targeting FGF8 subfamily members provides a new promising strategy for the treatment of oral diseases. The aim of this review was to summarize the aberrant regulations of FGF8 subfamily members and their potential implications in oral-maxillofacial diseases.

• Publisher: D.A. Spandidos,Spandidos Publications,Spandidos Publications UK Ltd
• Subject: Adapter proteins / Amino acids / Biopolymers / Care and treatment / Cell differentiation / Cellular signal transduction / Cleft lip / cleft lip and/or palate / CRISPR / Development and progression / Embryonic development / epithelial-to-mesenchymal transition / fibroblast growth factor 17 / fibroblast growth factor 18 / fibroblast growth factor 8 / Fibroblast growth factors / Gene expression / Genetic aspects / Genomes / Growth factors / Health aspects / Homeostasis / Kinases / Medical prognosis / Mouth diseases / Oral cancer / Peptides / Phosphorylation / Signal transduction / Stem cells