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Validation of the PI-RADS language: predictive values of PI-RADS lexicon descriptors for detection of prostate cancer
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Validation of the PI-RADS language: predictive values of PI-RADS lexicon descriptors for detection of prostate cancer
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Validation of the PI-RADS language: predictive values of PI-RADS lexicon descriptors for detection of prostate cancer
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Journal Article
Validation of the PI-RADS language: predictive values of PI-RADS lexicon descriptors for detection of prostate cancer
2020
Overview
ObjectivesTo assess the discriminatory power of lexicon terms used in PI-RADS version 2 to describe MRI features of prostate lesions.MethodsFour hundred fifty-four patients were included in this retrospective, institutional review board–approved study. Patients received multiparametric (mp) MRI and subsequent prostate biopsy including MRI/transrectal ultrasound fusion biopsy and 10-core systematic biopsy. PI-RADS lexicon terms describing lesion characteristics on mpMRI were assigned to lesions by experienced readers. Positive and negative predictive values (PPV, NPV) of each lexicon term were assessed using biopsy results as a reference standard.ResultsFrom a total of 501 lesions, clinically significant prostate cancer (csPCa) was present in 175 lesions (34.9%). Terms related to findings of restricted diffusion showed PPVs of up to 52.0%/43.9% and NPV of up to 91.8%/89.7% (peripheral zone or PZ/transition zone or TZ). T2-weighted imaging (T2W)–related terms showed a wide range of predictive values. For PZ lesions, high PPVs were found for “markedly hypointense,” “lenticular,” “lobulated,” and “spiculated” (PPVs between 67.2 and 56.7%). For TZ lesions, high PPVs were found for “water-drop-shaped” and “erased charcoal sign” (78.6% and 61.0%). The terms “encapsulated,” “organized chaos,” and “linear” showed to be good predictors for benignity with distinctively low PPVs between 5.4 and 6.9%. Most T2WI-related terms showed improved predictive values for TZ lesions when combined with DWI-related findings.ConclusionsLexicon terms with high discriminatory power were identified (e.g., “markedly hypointense,” “water-drop-shaped,” “organized chaos”). DWI-related terms can be useful for excluding TZ cancer. Combining T2WI- with DWI findings in TZ lesions markedly improved predictive values.Key Points• Lexicon terms describing morphological and functional features of prostate lesions on MRI show a wide range of predictive values for prostate cancer.• Some T2-related terms have favorable PPVs, e.g., “water-drop-shaped” and “organized chaos” while others show less distinctive predictive values. DWI-related terms have noticeable negative predictive values in TZ lesions making DWI feature a useful tool for exclusion of TZ cancer.• Combining DWI- and T2-related lexicon terms for assessment of TZ lesions markedly improves PPVs. Most T2-related lexicon terms showed a significant decrease in PPV when combined with negative findings for “DW hyperintensity.”
Publisher
Springer Nature B.V
Subject
