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Marine microbial L-glutaminase: from pharmaceutical to food industry
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Journal Article
Marine microbial L-glutaminase: from pharmaceutical to food industry
2021
Overview
Deamination of L-glutamine to glutamic acid with the concomitant release of ammonia by the activity of L-glutaminase (L-glutamine amidohydrolase EC 3.5.1.2) is a unique reaction that also finds potential applications in different sectors ranging from therapeutics to food industry. Owing to its cost-effectiveness, rapidity, and compatibility with downstream processes, microbial production of L-glutaminase is preferred over the production by other sources. Marine microorganisms including bacteria, yeasts, and moulds have manifested remarkable capacity to produce L-glutaminase and, therefore, are considered as prospective candidates for large-scale production of this enzyme. The main focus of this article is to provide an overview of L-glutaminase producing marine microorganisms, to discuss strategies used for the lab- and large-scale production of these enzyme and to review the application of L-glutaminase from marine sources so that the future prospects can be understood.Key points• L-glutaminase has potential applications in different sectors ranging from therapeutics to food industry• Marine microorganisms are considered as prospective candidates for large-scale production of L-glutaminase• Marine microbial L-glutaminase have great potential in therapeutics and in the food industry
Publisher
Springer Nature B.V
Subject
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