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Neocitreamicins I and II, Novel Antibiotics with Activity against Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci
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Neocitreamicins I and II, Novel Antibiotics with Activity against Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci
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Journal Article
Neocitreamicins I and II, Novel Antibiotics with Activity against Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci
2008
Overview
Two novel antibiotics, neocitreamicins I and II, were isolated from a fermentation broth of a
Nocardia
strain. This producing strain was obtained using an
in situ
diffusion chamber that facilitates the cultivation of soil microorganisms. The structures of neocitreamicins I and II were elucidated using UV, MS, and NMR data, and found to be related to the polycyclic xanthone antibiotics of the citreamicin class. The neocitreamicins showed
in vitro
activity against Gram-positive bacteria including strains of methicillin-resistant
Staphylococcus aureus
and vancomycin-resistant
Enterococcus faecalis
.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
Anti-Bacterial Agents - chemistry
/ Anti-Bacterial Agents - isolation & purification
/ Anti-Bacterial Agents - pharmacology
/ Bacteria
/ Biomedical and Life Sciences
/ MRSA
/ Nocardia
/ Nocardia - growth & development
/ Nocardia - isolation & purification
/ Oxazoles - isolation & purification
/ Staphylococcus aureus - drug effects
/ VRE
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