Asset Details
Do you wish to reserve the book?
A Class B Scavenger Receptor Mediates the Cellular Uptake of Carotenoids in Drosophila
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
A Class B Scavenger Receptor Mediates the Cellular Uptake of Carotenoids in Drosophila
Do you wish to request the book?
A Class B Scavenger Receptor Mediates the Cellular Uptake of Carotenoids in Drosophila
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
A Class B Scavenger Receptor Mediates the Cellular Uptake of Carotenoids in Drosophila
2002
Overview
Carotenoids are currently being intensely investigated regarding their potential to lower the risk of chronic disease and vitamin A deficiency. Invertebrate models in which vitamin A deficiency is not lethal allow the isolation of blind but viable mutants affected in the pathway leading from dietary carotenoids to vitamin A. Using a mutant in one of these model systems, Drosophila, the vitamin A-forming enzyme has recently been molecularly identified. We now show that the molecular basis for the blindness of a different Drosophila mutant, ninaD, is a defect in the cellular uptake of carotenoids. The ninaD gene encodes a class B scavenger receptor essential for the formation of the visual chromophore. A loss of this function results in a carotenoid-free and thus vitamin A-deficient phenotype. Our investigations provide molecular insight into how carotenoids may be distributed into cells of target tissues in animals and indicate a crucial role of class B scavenger receptors rendering dietary carotenoids available for subsequent cell metabolism, as needed for their various physiological functions.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
/ Animals
/ Drosophila Proteins - genetics
/ Drosophila Proteins - metabolism
/ genes
/ genetics
/ Genomics
/ Insect Proteins - metabolism
/ Lipids
/ Receptors, Immunologic - genetics
/ Receptors, Immunologic - metabolism
/ Receptors, Lipoprotein - genetics
/ Receptors, Lipoprotein - metabolism
