Journal Article

CSF TNF α levels were associated with conversion from mild cognitive impairment to dementia

Fu, Pan, Peng, Feifei

2022

Overview

We aimed to examine the association of CSF tumor necrosis factor-alpha (TNFα) with conversion from mild cognitive impairment (MCI) to dementia. At baseline, there were a total of 129 participants with MCI in this study. The association of CSF TNFα levels with the incidence of dementia were evaluated using Cox proportional hazards regression analysis adjusted for potential confounders. Individuals were categorized into groups based on the CSF TNFα tertiles. Compared to the low group (the reference group), the intermediate group progressed more rapidly to dementia [HR (95% CI) = 2.2 (1.15–4.1); p = 0.016] after adjusting for other covariates. However, the high group did not progress faster than the low group [HR (95% CI) = 1.5 (0.79–2.8); p = 0.214]. Our study suggested a potential non-relationship between CSF TNFα levels and the risk of development of dementia among MCI older people.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Aged / Alzheimer's disease / Biology and Life Sciences / Cerebrospinal fluid / Cognitive ability / Cognitive Dysfunction - epidemiology / Conversion / Cross-sectional studies / Dementia / Dementia disorders / Disease Progression / Gender / Genotype & phenotype / Humans / Impairment / Incidence / Medical imaging / Medicine and Health Sciences / Memory / Neuroimaging / Neuropsychological Tests / Older people / People and Places / Regression Analysis / Review boards / Tumor Necrosis Factor-alpha / Tumor necrosis factor-TNF / Tumor necrosis factor-α / Variables