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High-fiber diet ameliorates gut microbiota, serum metabolism and emotional mood in type 2 diabetes patients
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High-fiber diet ameliorates gut microbiota, serum metabolism and emotional mood in type 2 diabetes patients
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Journal Article
High-fiber diet ameliorates gut microbiota, serum metabolism and emotional mood in type 2 diabetes patients
2023
Overview
Previous studies have demonstrated that patients with type 2 diabetes mellitus (T2DM) often had the problems of fecal microbiota dysbiosis, and were usually accompanied with psychiatric comorbidities (such as depression and anxiety). Here, we conducted a randomized clinical study to analyze the changes in gut microbiota, serum metabolism and emotional mood of patients with T2DM after consumption of a high-fiber diet. The glucose homeostasis of participants with T2DM was improved by the high-fiber diet, and the serum metabolome, systemic inflammation and psychiatric comorbidities were also altered. The increased abundances of Lactobacillus , Bifidobacterium and Akkermansias revealed that the proportions of beneficial gut microbes were enriched by the high-fiber diet, while the abundances of Desulfovibrio , Klebsiella and other opportunistic pathogens were decreased. Therefore, the current study demonstrated that the intestinal microbiota alterations which were influenced by the high-fiber diet could improve the serum metabolism and emotional mood of patients with T2DM.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ Bacteria
/ Cellular and Infection Microbiology
/ Diabetes
/ Diabetes mellitus (non-insulin dependent)
/ Diabetes Mellitus, Type 2 - complications
/ Diabetes Mellitus, Type 2 - metabolism
/ Diet
/ Disease
/ Emotions
/ Feces
/ Food
/ Functional foods & nutraceuticals
/ Glucose
/ Humans
/ Obesity
/ Patients
/ Peptides
/ Software
/ Taxonomy
