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Endothelial microparticles: Sophisticated vesicles modulating vascular function

by Jonas, Rebecca , Syed, Wajihuddin , Mohler, Emile R , Rogers, Wade T , Edelberg, Jay , Curtis, Anne M , Moore, Jonni S

in Animals / Cell Communication / Cell-Derived Microparticles - metabolism / Cell-Derived Microparticles - pathology / Endothelial Cells - metabolism / Endothelial Cells - pathology / Endothelium, Vascular - metabolism / Endothelium, Vascular - pathology / Endothelium, Vascular - physiopathology / Humans / Signal Transduction / Vascular Diseases - metabolism / Vascular Diseases - pathology / Vascular Diseases - physiopathology / Vascular Diseases - therapy

2013

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Endothelial microparticles: Sophisticated vesicles modulating vascular function

by Jonas, Rebecca , Syed, Wajihuddin , Mohler, Emile R , Rogers, Wade T , Edelberg, Jay , Curtis, Anne M , Moore, Jonni S

2013

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Endothelial microparticles: Sophisticated vesicles modulating vascular function

by Jonas, Rebecca , Syed, Wajihuddin , Mohler, Emile R , Rogers, Wade T , Edelberg, Jay , Curtis, Anne M , Moore, Jonni S

2013

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Journal Article

Endothelial microparticles: Sophisticated vesicles modulating vascular function

Jonas, Rebecca,

Syed, Wajihuddin,

Mohler, Emile R,

Rogers, Wade T,

Edelberg, Jay,

Curtis, Anne M,

Moore, Jonni S

2013

Overview

Endothelial microparticles (EMPs) belong to a family of extracellular vesicles that are dynamic, mobile, biological effectors capable of mediating vascular physiology and function. The release of EMPs can impart autocrine and paracrine effects on target cells through surface interaction, cellular fusion, and, possibly, the delivery of intra-vesicular cargo. A greater understanding of the formation, composition, and function of EMPs will broaden our understanding of endothelial communication and may expose new pathways amenable for therapeutic manipulation.

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Publisher

SAGE Publications,Sage Publications Ltd

Subject

Animals

/ Cell Communication

/ Cell-Derived Microparticles - metabolism

/ Cell-Derived Microparticles - pathology

/ Endothelial Cells - metabolism

/ Endothelial Cells - pathology

/ Endothelium, Vascular - metabolism