Asset Details
Do you wish to reserve the book?
Antimicrobial activity of enterocins from Enterococcus faecalis SL-5 against Propionibacterium acnes, the causative agent in acne vulgaris, and its therapeutic effect
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Antimicrobial activity of enterocins from Enterococcus faecalis SL-5 against Propionibacterium acnes, the causative agent in acne vulgaris, and its therapeutic effect
Do you wish to request the book?
Antimicrobial activity of enterocins from Enterococcus faecalis SL-5 against Propionibacterium acnes, the causative agent in acne vulgaris, and its therapeutic effect
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Antimicrobial activity of enterocins from Enterococcus faecalis SL-5 against Propionibacterium acnes, the causative agent in acne vulgaris, and its therapeutic effect
2009
Overview
A lactic acid bacterial strain was isolated from human fecal specimen and identified as
Enterococcus faecalis
SL-5. The isolated strain showed antimicrobial activity against Gram-positive pathogens assayed, especially the highest activity against
Propionibacterium acnes
. The antimicrobial substance was purified and verified as a bacteriocin (named ESL5) of
E. faecalis
SL-5 by activity-staining using
P. acnes
as an indicator. N-terminal sequence of ESL5 was determined (MGAIAKLVAK) and sequence analysis revealed that it is almost identical to the some of enterocins including L50A/B of
E. faecium
L50 and MR10A/B of
E. faecalis
MRR 10-3. From the sequencing data of L50A/B structural genes, the nucleotide sequence showed 100% identity with that of the MR10A/B structural genes, implying that ESL5 is an equivalent of enterocin MR10. Meanwhile, we also tested the therapeutic effect of anti-
P. acnes
activity in patients with mild to moderate acne because of its pathogenic role to acne vulgaris. For this purpose, a concentrated powder of CBT SL-5 was prepared using cell-free culture supernatant (CFCS) of
E. faecalis
SL-5 and included in a lotion for application in the patients. The study showed that CBT SL-5 lotion significantly reduced the inflammatory lesions like pustules compared to the placebo lotion. Therefore our results indicate that the anti-
P. acnes
activity produced by
E. faecalis
SL-5 has potential role to the treatment of acne as an alternative to topical antibiotics.
Publisher
Springer Science and Business Media LLC,The Microbiological Society of Korea,Springer Nature B.V,한국미생물학회
Subject
/ Acne Vulgaris - drug therapy
/ Adult
/ Anti-Bacterial Agents - administration & dosage
/ Anti-Bacterial Agents - biosynthesis
/ Anti-Bacterial Agents - isolation & purification
/ Bacteriocins - administration & dosage
/ Bacteriocins - isolation & purification
/ Biomedical and Life Sciences
/ Child
/ E coli
/ Enterococcus faecalis - genetics
/ Enterococcus faecalis - isolation & purification
/ Enterococcus faecalis - metabolism
/ Feces
/ Humans
/ Listeria
/ Propionibacterium acnes - drug effects
/ 생물학
We currently cannot retrieve any items related to this title. Kindly check back at a later time.