Journal Article

Nasogastric Tube Feeding in Children with Cancer: The Effect of Two Different Formulas on Weight, Body Composition, and Serum Protein Concentrations

Lippens, Robert J. J., van den Berg, Anneke M. J., van Houdt, Nicole B. M., Tolboom, Jules J. M., den Broeder, Eline, Hofman, Zandrie, Sengers, Robert C. A., van Staveren, Wija A., van 't Hof, Martin A.

2000

Overview

Background: Treatment of cancer cachexia partly involves the administration of adequate amounts of energy. The aim of this study was to assess the tolerance and efficacy of two equal volumes of tube feeding, one with a standard (1 kcal/mL) and one with a high energy density (1.5 kcal/mL), during the intensive phase of treatment. Methods: Nutritional status was assessed weekly, in 27 children with a solid tumor, by measuring weight, height, midupper arm circumference, biceps and triceps skinfold, and serum proteins. Tolerance was assessed by recording the occurrence of vomiting and by expressing the administered volume as a percentage of the required volume. Results: Both formulas were equally well tolerated, leading to a significantly higher energy intake in the energy-enriched formula group. In both formula groups, all anthropometric variables increased significantly (range of mean increase, 5.2% to 25.5%; p < .05) during the first 4 weeks of intervention. Between 4 and 10 weeks, variables continued to increase significantly in the energy-enriched group, resulting in adequate repletion, in contrast to the standard formula group. The concentration of serum proteins, low at initiation of tube feeding, returned to the normal range within 2 to 4 weeks with no significant differences between the two groups. Conclusions: The energy-enriched formula was more effective in improving the nutritional status of children with cancer during the intensive phase of treatment than the standard formula. Intensive, protocolized administration of an energy-enriched formula should therefore be initiated as soon as one of the criteria for initiation of tube feeding is met. (Journal of Parenteral and Enteral Nutrition 24:351-360, 2000)

• Publisher: Sage Publications,SAGE Publications,ASPEN,American Society for Parenteral and Enteral Nutrition
• Subject: Adolescent / Afdeling Humane voeding / Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy / Anthropometry / Biological and medical sciences / Blood Proteins - analysis / Body Composition / Body Weight / Cachexia - therapy / Child / Child, Preschool / Double-Blind Method / Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition / Energy Intake / Enteral Nutrition / Food, Formulated / Human Nutrition / Human Nutrition & Health / Human Nutrition (HNE) / Humane Voeding / Humane Voeding & Gezondheid / Humans / Infant / Intensive care medicine / Intubation, Gastrointestinal / Medical sciences / Neoplasms - complications / Nutritional Status / Prospective Studies / Time Factors / Treatment Outcome / VLAG