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Responsive Accumulation of Nanohybrids to Boost NIR‐Phototheranostics for Specific Tumor Imaging and Glutathione Depletion‐Enhanced Synergistic Therapy
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Responsive Accumulation of Nanohybrids to Boost NIR‐Phototheranostics for Specific Tumor Imaging and Glutathione Depletion‐Enhanced Synergistic Therapy
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Journal Article
Responsive Accumulation of Nanohybrids to Boost NIR‐Phototheranostics for Specific Tumor Imaging and Glutathione Depletion‐Enhanced Synergistic Therapy
2023
Overview
Dynamic regulation of nanoparticles in a controllable manner has great potential in various areas. Compared to the individual nanoparticles, the assembled nanoparticles exhibit superior properties and functions, which can be applied to achieve desirable performances. Here, a pH‐responsive i‐motif DNA‐mediated strategy to tailor the programmable behaviors of erbium‐based rare‐earth nanoparticles (ErNPs) decorated copper doped metal‐organic framework (CPM) nanohybrids (ECPM) under physiological conditions is reported. Within the acidic tumor microenvironment, the i‐motif DNA strands are able to form quadruplex structures, resulting in the assembly of nanohybrids and selective tumor accumulation, which further amplify the ErNPs downconversion emission (1550 nm) signal for imaging. Meanwhile, the ECPM matrix acts as a near‐infrared (NIR) photon‐activated reactive oxygen species (ROS) amplifier through the singlet oxygen generation of the matrix in combination with its ability of intracellular glutathione depletion upon irradiation. In short, this work displays a classical example of engineering of nanoparticles, which will manifest the importance of developing nanohybrids with structural programmability in biomedical applications. “Unity makes strength,” the smart use of MOF‐based nanohybrid (ECPM) for depleting the intracellular GSH and thus increasing the delivery efficiency of the ECPM is reported. The unique acidity‐responsive assembly of ECPM enables in situ clustering of the nanohybrid in the acidic tumor microenvironment (TME), which can achieve NIR‐activated tumor‐specific cancer theranostics with negligible side effects.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
