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CDKB1;1 Forms a Functional Complex with CYCA2;3 to Suppress Endocycle Onset
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CDKB1;1 Forms a Functional Complex with CYCA2;3 to Suppress Endocycle Onset
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Journal Article
CDKB1;1 Forms a Functional Complex with CYCA2;3 to Suppress Endocycle Onset
2009
Overview
The mitosis-to-endocycle transition requires the controlled inactivation of M phase-associated cyclin-dependent kinase (CDK) activity. Previously, the B-type CDKB1;1 was identified as an important negative regulator of endocycle onset. Here, we demonstrate that CDKB1;1 copurifies and associates with the A2-type cyclin CYCA2;3. Coexpression of CYCA2;3 with CDKB1;1 triggered ectopic cell divisions and inhibited endoreduplication. Moreover, the enhanced endoreduplication phenotype observed after overexpression of a dominant-negative allele of CDKB1;1 could be partially complemented by CYCA2;3 co-overexpression, illustrating that both subunits unite in vivo to form a functional complex. CYCA2;3 protein stability was found to be controlled by CCS52A1, an activator of the anaphase-promoting complex. We conclude that CCS52A1 participates in endocycle onset by down-regulating CDKB1;1 activity through the destruction of CYCA2;3.
Publisher
American Society of Plant Biologists
Subject
/ analysis
/ Arabidopsis Proteins - analysis
/ Arabidopsis Proteins - genetics
/ Arabidopsis Proteins - metabolism
/ Arabidopsis Proteins - physiology
/ Biological and medical sciences
/ Cell Cycle Proteins - metabolism
/ Cell Cycle Proteins - physiology
/ Cyclin A
/ Cyclin-Dependent Kinases - analysis
/ Cyclin-Dependent Kinases - genetics
/ Cyclin-Dependent Kinases - physiology
/ Cyclins
/ DNA
/ Fundamental and applied biological sciences. Psychology
/ genetics
/ Green Fluorescent Proteins - analysis
/ Plant physiology and development
/ Plants
/ Proteins
