Journal Article

Salivary Metabolites Produced by Oral Microbes in Oral Diseases and Oral Squamous Cell Carcinoma: A Review

Kullaa, Arja, Kashyap, Bina

2024

Overview

In recent years, salivary metabolome studies have provided new biological information and salivary biomarkers to diagnose different diseases at early stages. The saliva in the oral cavity is influenced by many factors that are reflected in the salivary metabolite profile. Oral microbes can alter the salivary metabolite profile and may express oral inflammation or oral diseases. The released microbial metabolites in the saliva represent the altered biochemical pathways in the oral cavity. This review highlights the oral microbial profile and microbial metabolites released in saliva and its use as a diagnostic biofluid for different oral diseases. The importance of salivary metabolites produced by oral microbes as risk factors for oral diseases and their possible relationship in oral carcinogenesis is discussed.

• Publisher: MDPI AG
• Subject: Analysis / Bacteria / Biofilms / Biological markers / Biomarkers / Carbohydrates / Carcinogenesis / Carcinogens / Care and treatment / Chromatography / Dental caries / Dental plaque / Diagnosis / dysbiosis / Gum disease / Human papillomavirus / Hydrogen peroxide / Medical prognosis / Metabolism / Metabolites / Microorganisms / Mouth cancer / NMR / Nuclear magnetic resonance / Oral cancer / Oral carcinoma / Oral cavity / oral disease / Oral diseases / oral microbiome / Oral squamous cell carcinoma / Proteins / Risk factors / Saliva / Squamous cell carcinoma / Systemic diseases / Tongue / Viruses