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The Junction-Associated Protein, Zonula Occludens-1, Localizes to the Nucleus before the Maturation and during the Remodeling of Cell-Cell Contacts
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The Junction-Associated Protein, Zonula Occludens-1, Localizes to the Nucleus before the Maturation and during the Remodeling of Cell-Cell Contacts
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Journal Article
The Junction-Associated Protein, Zonula Occludens-1, Localizes to the Nucleus before the Maturation and during the Remodeling of Cell-Cell Contacts
1996
Overview
The junction-associated protein zonula occludens-1 (ZO-1) is a member of a family of membrane-associated guanylate kinase homologues thought to be important in signal transduction at sites of cell-cell contact. We present evidence that under certain conditions of cell growth, ZO-1 can be detected in the nucleus. Two different antibodies against distinct portions of the ZO-1 polypeptide reveal nuclear staining in subconfluent, but not confluent, cell cultures. An exogenously expressed, epitope-tagged ZO-1 can also be detected in the nuclei of transfected cells. Nuclear accumulation can be stimulated at sites of wounding in cultured epithelial cells, and immunoperoxidase detection of ZO-1 in tissue sections of intestinal epithelial cells reveals nuclear labeling only along the outer tip of the villus. These results suggest that the nuclear localization of ZO-1 is inversely related to the extent and/or maturity of cell contact. Since cell-cell contacts are specialized sites for signaling pathways implicated in growth and differentiation, we suggest that the nuclear accumulation of ZO-1 may be relevant for its suggested role in membrane-associated guanylate kinase homologue signal transduction.
Publisher
National Academy of Sciences of the United States of America,National Acad Sciences
