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Improved donor chimerism in relapse myelofibrosis post allogenic stem cell transplant with azacitidine and oral decitabine—First case report
by
Sibai, Hassan
, Cheung, Verna
, Michelis, Fotios V.
in
5-aza-2'-deoxycytidine
/ allogenic stem cell transplant
/ Anemia
/ Biopsy
/ Bone marrow
/ Case Report
/ Case Reports
/ Chimerism
/ Disease control
/ hypomethylating agent
/ Leukopenia
/ Myelofibrosis
/ myeloid lineage chimerism
/ Neutropenia
/ Patients
/ primary myelofibrosis
/ Quality of life
/ Remission (Medicine)
/ Stem cell transplantation
2023
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Improved donor chimerism in relapse myelofibrosis post allogenic stem cell transplant with azacitidine and oral decitabine—First case report
by
Sibai, Hassan
, Cheung, Verna
, Michelis, Fotios V.
in
5-aza-2'-deoxycytidine
/ allogenic stem cell transplant
/ Anemia
/ Biopsy
/ Bone marrow
/ Case Report
/ Case Reports
/ Chimerism
/ Disease control
/ hypomethylating agent
/ Leukopenia
/ Myelofibrosis
/ myeloid lineage chimerism
/ Neutropenia
/ Patients
/ primary myelofibrosis
/ Quality of life
/ Remission (Medicine)
/ Stem cell transplantation
2023
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Improved donor chimerism in relapse myelofibrosis post allogenic stem cell transplant with azacitidine and oral decitabine—First case report
by
Sibai, Hassan
, Cheung, Verna
, Michelis, Fotios V.
in
5-aza-2'-deoxycytidine
/ allogenic stem cell transplant
/ Anemia
/ Biopsy
/ Bone marrow
/ Case Report
/ Case Reports
/ Chimerism
/ Disease control
/ hypomethylating agent
/ Leukopenia
/ Myelofibrosis
/ myeloid lineage chimerism
/ Neutropenia
/ Patients
/ primary myelofibrosis
/ Quality of life
/ Remission (Medicine)
/ Stem cell transplantation
2023
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Improved donor chimerism in relapse myelofibrosis post allogenic stem cell transplant with azacitidine and oral decitabine—First case report
Journal Article
Improved donor chimerism in relapse myelofibrosis post allogenic stem cell transplant with azacitidine and oral decitabine—First case report
2023
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Overview
To date, allogenic stem cell transplant (ASCT) remains the only potential curative option for patients with primary myelofibrosis (PMF). However, relapse rates and associated mortality remain a concern. A second ASCT may not be feasible due to advancing age, declined functional status, donor unavailability, toxicities associated with a second ASCT. Herein, we report the first case of utilizing initially azacitidine and subsequently oral decitabine + cedazuridine (decitabine), in the context of relapsed PMF post‐ASCT. Utilizing both hypomethylating agents provided disease control and improved donor/myeloid lineage chimerism levels, and the patient also remained transfusion independent, with preserved functional status and quality of life.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
Subject
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