Journal Article

Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases

Alves, Rayanne Maira Felix Ribeiro, de Lima Silva, Sonaly, da Silva, Tays A. F., de Menezes, Geovânia Maria Sales, dos Santos, Pablo Ferreira, Schini-Kerth, Valérie B., Dantas, Sabine Helena, Almeida, Arthur José Pontes Oliveira de, de Almeida Rezende, Mathania Silva, Medeiros, Isac Almeida de, de Oliveira, Júlio César Pinheiro Lúcio, de Azevedo, Fátima de L. A. A.

2020

Overview

The global population above 60 years has been growing exponentially in the last decades, which is accompanied by an increase in the prevalence of age-related chronic diseases, highlighting cardiovascular diseases (CVDs), such as hypertension, atherosclerosis, and heart failure. Aging is the main risk factor for these diseases. Such susceptibility to disease is explained, at least in part, by the increase of oxidative stress, in which it damages cellular components such as proteins, DNA, and lipids. In addition, the chronic inflammatory process in aging “inflammaging” also contributes to cell damage, creating a stressful environment which drives to the development of CVDs. Taken together, it is possible to identify the molecular connection between oxidative stress and the inflammatory process, especially by the crosstalk between the transcription factors Nrf-2 and NF-κB which are mediated by redox signalling and are involved in aging. Therapies that control this process are key targets in the prevention/combat of age-related CVDs. In this review, we show the basics of inflammation and oxidative stress, including the crosstalk between them, and the implications on age-related CVDs.

• Publisher: Hindawi Publishing Corporation,Hindawi,John Wiley & Sons, Inc
• Subject: Age / Aging / Aging - pathology / Animals / Atherosclerosis / Autophagy / Bioavailability / Canada / Cardiovascular disease / Cardiovascular Diseases - pathology / Cardiovascular system / Collagen / Cytokines / Diseases / Endothelium / Homeostasis / Humans / Hypertension / Immune system / Inflammation / Inflammation - pathology / Liu, Timothy / Microbiota / Models, Biological / Older people / Oxidative Stress / Pathogens / Physiology / Proteins / Reactive Oxygen Species - metabolism / Review / Senescence