Journal Article

Comparative cost-effectiveness of surgery, angioplasty, or medical therapy in patients with multivessel coronary artery disease: MASS II trial

Rocca, Hans-Peter Brunner-La, Rezende, Paulo Cury, Bocchi, Edimar Alcides, Takiuti, Myrthes Emy, Hueb, Whady, Ju, Yang Ting, de Lima, Antonio Carlos Pedroso, Brandão, Sara Michelly Gonçalves

2018

Overview

Background The costs for treating coronary artery disease (CAD) are high worldwide. We performed a prespecified analyses of cost-effectiveness of three therapeutic strategies for multivessel CAD. Methods From May 1995 to May 2000, a total of 611 patients were randomly assigned to coronary artery bypass graft (CABG), n = 203; percutaneous coronary intervention (PCI), n = 205; or medical treatment (MT), n = 203. This cost analysis study was based on the perspective of the Public Health Care System. Initial procedural and follow-up costs for medications, cardiology examinations, and hospitalizations for complications were calculated after randomization. Life-years and quality-adjusted life years (QALYs) were used as effectiveness measures. Incremental cost-effectiveness ratios (ICER) were obtained by using nonparametric bootstrapping methods with 5000 resamples. Results Initial procedural costs were lower for MT. However, the subsequent 5-year cumulative costs were lower for CABG. Compared with baseline, the three treatment options produced significant improvements in QALYs. After 5 years, PCI and CABG had better QALYs results compared with MT. The ICER results favored CABG and PCI, and favored PCI over CABG in 61% of the drawings. On the other hand, sensitivity analysis showed MT as the preferred therapy compared with CABG and PCI, in the analysis considering higher costs. Conclusions At 5-year follow-up, the three treatment options yielded improvements in quality of life, with comparable and acceptable costs. However, despite higher initial costs, the comparison of cost-effectiveness after 5 years of follow-up among the three treatments showed both interventions (CABG and PCI) to be cost-effective strategies compared with MT. Trial registration ISRCTN, ISRCTN66068876, Registered 06/10/1994, http://www.controlled-trials.com/ISRCTN66068876

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: American dollar / Angina pectoris / Angioplasty / Bare metal stent / Bootstrap method / Cardiovascular disease / Clinical trials / Coronary bypass surgery / Coronary vessels / Cost analysis / Cost–benefit analysis / Diabetes / GDP / Gross Domestic Product / Health Administration / Health care expenditures / Health Economics / Health Services Research / Heart attacks / Heart surgery / Hospitalization / Intervention / Medical treatment / Medicine / Medicine & Public Health / Milk, Harvey / Patients / Per capita / Percutaneous coronary intervention / Pharmacoeconomics and Health Outcomes / Public Health / Quality of life / Quality of Life Research / Review / Sensitivity analysis / Stents / Values / Vein & artery diseases